| C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins S Mizielinska, S Grönke, T Niccoli, CE Ridler, EL Clayton, A Devoy, ... Science 345 (6201), 1192-1194, 2014 | 774 | 2014 |
| Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy Z Jaunmuktane, S Mead, M Ellis, JDF Wadsworth, AJ Nicoll, J Kenny, ... Nature 525 (7568), 247-250, 2015 | 563 | 2015 |
| C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexes P Fratta, S Mizielinska, AJ Nicoll, M Zloh, EMC Fisher, G Parkinson, ... Scientific reports 2 (1), 1016, 2012 | 383 | 2012 |
| Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites DB Freir, AJ Nicoll, I Klyubin, S Panico, JM Mc Donald, E Risse, ... Nature communications 2 (1), 336, 2011 | 343 | 2011 |
| Amyloid β-protein dimers rapidly form stable synaptotoxic protofibrils B O'Nuallain, DB Freir, AJ Nicoll, E Risse, N Ferguson, CE Herron, ... Journal of Neuroscience 30 (43), 14411-14419, 2010 | 317 | 2010 |
| G‐quadruplex‐binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo R Simone, R Balendra, TG Moens, E Preza, KM Wilson, A Heslegrave, ... EMBO molecular medicine 10 (1), 22-31, 2018 | 209 | 2018 |
| mGlu5 receptors and cellular prion protein mediate amyloid-β-facilitated synaptic long-term depression in vivo NW Hu, AJ Nicoll, D Zhang, AJ Mably, T O’Malley, SA Purro, C Terry, ... Nature communications 5 (1), 3374, 2014 | 205 | 2014 |
| Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity AJ Nicoll, S Panico, DB Freir, D Wright, C Terry, E Risse, CE Herron, ... Nature communications 4 (1), 2416, 2013 | 142 | 2013 |
| Pharmacological chaperone for the structured domain of human prion protein AJ Nicoll, CR Trevitt, MH Tattum, E Risse, E Quarterman, AA Ibarra, ... Proceedings of the National Academy of Sciences 107 (41), 17610-17615, 2010 | 101 | 2010 |
| Peripheral administration of a humanized anti-PrP antibody blocks Alzheimer's disease Aβ synaptotoxicity I Klyubin, AJ Nicoll, A Khalili-Shirazi, M Farmer, S Canning, A Mably, ... Journal of Neuroscience 34 (18), 6140-6145, 2014 | 88 | 2014 |
| Prion protein as a toxic acceptor of amyloid-β oligomers SA Purro, AJ Nicoll, J Collinge Biological psychiatry 83 (4), 358-368, 2018 | 77 | 2018 |
| Nucleophilic and general acid catalysis at physiological pH by a designed miniature esterase AJ Nicoll, RK Allemann Organic & biomolecular chemistry 2 (15), 2175-2180, 2004 | 55 | 2004 |
| Preventing prion pathogenicity by targeting the cellular prion protein AJ Nicoll, J Collinge Infectious Disorders-Drug Targets (Formerly Current Drug Targets-Infectious …, 2009 | 54 | 2009 |
| Designed high affinity Cu2+-binding α-helical foldamer AJ Nicoll, DJ Miller, K Fütterer, R Ravelli, RK Allemann Journal of the American Chemical Society 128 (28), 9187-9193, 2006 | 52 | 2006 |
| Identification of a compound that disrupts binding of amyloid-β to the prion protein using a novel fluorescence-based assay E Risse, AJ Nicoll, WA Taylor, D Wright, M Badoni, X Yang, MA Farrow, ... Journal of Biological Chemistry 290 (27), 17020-17028, 2015 | 43 | 2015 |
| N-terminal domain of prion protein directs its oligomeric association CR Trevitt, LLP Hosszu, M Batchelor, S Panico, C Terry, AJ Nicoll, E Risse, ... Journal of Biological Chemistry 289 (37), 25497-25508, 2014 | 30 | 2014 |
| De novo design of a stable N-terminal helical foldamer AJ Nicoll, CJ Weston, C Cureton, C Ludwig, F Dancea, N Spencer, ... Organic & biomolecular chemistry 3 (24), 4310-4315, 2005 | 15 | 2005 |
| Soluble Aβ aggregates can inhibit prion propagation CJ Sarell, E Quarterman, DCM Yip, C Terry, AJ Nicoll, JDF Wadsworth, ... Open Biology 7 (11), 170158, 2017 | 12 | 2017 |
| SIP 5: Social distancing during a pandemic. Not sexy, but sometimes effective: social distancing and non-pharmaceutical interventions. A Osterhaus, C Vanlangendonck | 9 | 2009 |
| Differential specific radiation damage in the CuII-bound and PdII-bound forms of an α-helical foldamer: a case study of crystallographic phasing by RIP and SAD K Fütterer, RBG Ravelli, SA White, AJ Nicoll, RK Allemann Acta Crystallographica Section D: Biological Crystallography 64 (3), 264-272, 2008 | 9 | 2008 |
