| Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal I Fares, J Chagraoui, Y Gareau, S Gingras, R Ruel, N Mayotte, E Csaszar, ... Science 345 (6203), 1509-1512, 2014 | 636 | 2014 |
| Mubritinib targets the electron transport chain complex I and reveals the landscape of OXPHOS dependency in acute myeloid leukemia I Baccelli, Y Gareau, B Lehnertz, S Gingras, JF Spinella, S Corneau, ... Cancer cell 36 (1), 84-99. e8, 2019 | 212 | 2019 |
| Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1–2 safety and feasibility study S Cohen, J Roy, S Lachance, JS Delisle, A Marinier, L Busque, DC Roy, ... The Lancet Haematology 7 (2), e134-e145, 2020 | 190 | 2020 |
| The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias VP Lavallée, I Baccelli, J Krosl, B Wilhelm, F Barabé, P Gendron, ... Nature genetics 47 (9), 1030-1037, 2015 | 169 | 2015 |
| Identification of small molecules that support human leukemia stem cell activity ex vivo C Pabst, J Krosl, I Fares, G Boucher, R Ruel, A Marinier, S Lemieux, ... Nature methods 11 (4), 436-442, 2014 | 158 | 2014 |
| Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation N Thevakumaran, H Lavoie, DA Critton, A Tebben, A Marinier, F Sicheri, ... Nature structural & molecular biology 22 (1), 37-43, 2015 | 147 | 2015 |
| Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding PC Wong, D Seiffert, JE Bird, CA Watson, JS Bostwick, M Giancarli, ... Science translational medicine 9 (371), eaaf5294, 2017 | 145 | 2017 |
| Rational design of RAR‐selective ligands revealed by RARβ crystal stucture P Germain, S Kammerer, E Pérez, C Peluso‐Iltis, D Tortolani, FC Zusi, ... EMBO reports 5 (9), 877-882, 2004 | 118 | 2004 |
| E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin H Huang, DF Ceccarelli, S Orlicky, DJ St-Cyr, A Ziemba, P Garg, ... Nature chemical biology 10 (2), 156-163, 2014 | 94 | 2014 |
| Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors VP Lavallée, J Krosl, S Lemieux, G Boucher, P Gendron, C Pabst, I Boivin, ... Blood, The Journal of the American Society of Hematology 127 (24), 3054-3061, 2016 | 86 | 2016 |
| Genetic characterization of ABT-199 sensitivity in human AML R Bisaillon, C Moison, C Thiollier, J Krosl, ME Bordeleau, B Lehnertz, ... Leukemia 34 (1), 63-74, 2020 | 79 | 2020 |
| Sordaricin antifungal agents CA Quesnelle, P Gill, M Dodier, DS Laurent, M Serrano-Wu, A Marinier, ... Bioorganic & medicinal chemistry letters 13 (3), 519-524, 2003 | 77 | 2003 |
| Tyrosine kinase inhibitors MD Wittman, N Balasubramanian, U Velaparthi, K Zimmermann, ... US Patent 7,081,454, 2006 | 75 | 2006 |
| UM171 preserves epigenetic marks that are reduced in ex vivo culture of human HSCs via potentiation of the CLR3-KBTBD4 complex J Chagraoui, S Girard, JF Spinella, L Simon, E Bonneil, N Mayotte, ... Cell Stem Cell 28 (1), 48-62. e6, 2021 | 65 | 2021 |
| Serine 232 and methionine 272 define the ligand binding pocket in retinoic acid receptor subtypes J Ostrowski, T Roalsvig, L Hammer, A Marinier, JE Starrett, KL Yu, ... Journal of Biological Chemistry 273 (6), 3490-3495, 1998 | 52 | 1998 |
| Chemogenomic Landscape of RUNX1-mutated AML Reveals Importance of RUNX1 Allele Dosage in Genetics and Glucocorticoid Sensitivity L Simon, VP Lavallée, ME Bordeleau, J Krosl, I Baccelli, G Boucher, ... Clinical cancer research 23 (22), 6969-6981, 2017 | 49 | 2017 |
| Malonate derivatives of glycolipids as cell adhesion inhibitors A Marinier, A Martel US Patent 5,747,463, 1998 | 49 | 1998 |
| Synergistic cytotoxicity exhibited by combination treatment of selective retinoid ligands with taxol (Paclitaxel) V Vivat-Hannah, D You, C Rizzo, JP Daris, P Lapointe, FC Zusi, ... Cancer research 61 (24), 8703-8711, 2001 | 48 | 2001 |
| Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials LB Snyder, Z Meng, R Mate, SV D’Andrea, A Marinier, CA Quesnelle, ... Bioorganic & medicinal chemistry letters 14 (18), 4735-4739, 2004 | 47 | 2004 |
| Thiophene-based tricyclic compounds and pharmaceutical compositions comprising same M Belema, A Bunker, V Nguyen, F Beaulieu, C Ouellet, A Marinier, S Roy, ... US Patent 6,933,294, 2005 | 46 | 2005 |
