受强制性开放获取政策约束的文章 - Andrea Testa了解详情
可在其他位置公开访问的文章：31 篇
Structural basis of PROTAC cooperative recognition for selective protein degradation
MS Gadd, A Testa, X Lucas, KH Chan, W Chen, DJ Lamont, M Zengerle, ...
Nature Chemical Biology 13 (5), 514-521, 2017
强制性开放获取政策： UK Biotechnology and Biological Sciences Research Council, Wellcome Trust …
Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based …
V Zoppi, SJ Hughes, C Maniaci, A Testa, T Gmaschitz, C Wieshofer, ...
Journal of medicinal chemistry 62 (2), 699-726, 2018
强制性开放获取政策： Wellcome Trust, European Commission
Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation
C Maniaci, SJ Hughes, A Testa, W Chen, DJ Lamont, S Rocha, DR Alessi, ...
Nature communications 8 (1), 830, 2017
强制性开放获取政策： Cancer Research UK, UK Medical Research Council, Wellcome Trust, European …
Impact of target warhead and linkage vector on inducing protein degradation: comparison of bromodomain and extra-terminal (BET) degraders derived from triazolodiazepine (JQ1 …
KH Chan, M Zengerle, A Testa, A Ciulli
Journal of medicinal chemistry 61 (2), 504-513, 2018
强制性开放获取政策： UK Biotechnology and Biological Sciences Research Council, Wellcome Trust …
Structure‐Based Design of a Macrocyclic PROTAC
A Testa, SJ Hughes, X Lucas, JE Wright, A Ciulli
Angewandte Chemie 132 (4), 1744-1751, 2020
强制性开放获取政策： Wellcome Trust, European Commission
Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity
S Imaide, KM Riching, N Makukhin, V Vetma, C Whitworth, SJ Hughes, ...
Nature chemical biology 17 (11), 1157-1167, 2021
强制性开放获取政策： UK Medical Research Council, Wellcome Trust, European Commission
Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs
M Girardini, C Maniaci, SJ Hughes, A Testa, A Ciulli
Bioorganic & medicinal chemistry 27 (12), 2466-2479, 2019
强制性开放获取政策： Wellcome Trust, European Commission, Government of Italy
3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation
A Testa, X Lucas, GV Castro, KH Chan, JE Wright, AC Runcie, MS Gadd, ...
Journal of the American Chemical Society 140 (29), 9299-9313, 2018
强制性开放获取政策： UK Biotechnology and Biological Sciences Research Council, Wellcome Trust …
Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader
H Tovell, A Testa, C Maniaci, H Zhou, AR Prescott, T Macartney, A Ciulli, ...
ACS chemical biology 14 (5), 882-892, 2019
强制性开放获取政策： UK Biotechnology and Biological Sciences Research Council, UK Medical …
Understanding and improving the membrane permeability of VH032-based PROTACs
VG Klein, CE Townsend, A Testa, M Zengerle, C Maniaci, SJ Hughes, ...
ACS medicinal chemistry letters 11 (9), 1732-1738, 2020
强制性开放获取政策： US National Science Foundation, US National Institutes of Health, UK …
Design and characterization of SGK3-PROTAC1, an isoform specific SGK3 kinase PROTAC degrader
H Tovell, A Testa, H Zhou, N Shpiro, C Crafter, A Ciulli, DR Alessi
ACS chemical biology 14 (9), 2024-2034, 2019
强制性开放获取政策： UK Biotechnology and Biological Sciences Research Council, UK Medical …
Development of BromoTag: A “Bump-and-Hole”–PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins
AG Bond, C Craigon, KH Chan, A Testa, A Karapetsas, R Fasimoye, ...
Journal of Medicinal Chemistry 64 (20), 15477-15502, 2021
强制性开放获取政策： UK Medical Research Council, Wellcome Trust, European Commission
Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders
A Hanzl, R Casement, H Imrichova, SJ Hughes, E Barone, A Testa, ...
Nature chemical biology 19 (3), 323-333, 2023
强制性开放获取政策： Austrian Science Fund, UK Biotechnology and Biological Sciences Research …
New molecular and therapeutic insights into canine diffuse large B cell lymphoma elucidates the role of the dog as a model for human disease
L Aresu, S Ferraresso, L Marconato, L Cascione, S Napoli, E Gaudio, ...
Blood, The Journal of the American Society of Hematology 132 (Supplement 1 …, 2018
强制性开放获取政策： Government of Italy
Targeted protein degradation via intramolecular bivalent glues
O Hsia, M Hinterndorfer, AD Cowan, K Iso, T Ishida, R Sundaramoorthy, ...
Nature 627 (8002), 204-211, 2024
强制性开放获取政策： Austrian Science Fund, Wellcome Trust, European Commission
Inducible degradation of target proteins through a tractable affinity-directed protein missile system
LM Simpson, TJ Macartney, A Nardin, LJ Fulcher, S Röth, A Testa, ...
Cell Chemical Biology 27 (9), 1164-1180. e5, 2020
强制性开放获取政策： UK Medical Research Council, European Commission
Optimization of a “bump-and-hole” approach to allele-selective BET bromodomain inhibition
AC Runcie, M Zengerle, KH Chan, A Testa, L van Beurden, MGJ Baud, ...
Chemical Science 9 (9), 2452-2468, 2018
强制性开放获取政策： UK Biotechnology and Biological Sciences Research Council, UK Medical …
Mind the metal: a fragment library-derived zinc impurity binds the E2 ubiquitin-conjugating enzyme Ube2T and induces structural rearrangements
FE Morreale, A Testa, VK Chaugule, A Bortoluzzi, A Ciulli, H Walden
Journal of medicinal chemistry 60 (19), 8183-8191, 2017
强制性开放获取政策： European Molecular Biology Laboratory, UK Biotechnology and Biological …
Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2
S Ramachandran, N Makukhin, K Haubrich, M Nagala, B Forrester, ...
Nature Communications 14 (1), 6345, 2023
强制性开放获取政策： Wellcome Trust, European Commission
Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms
C Grohmann, CM Magtoto, JR Walker, NK Chua, A Gabrielyan, M Hall, ...
Nature Communications 13 (1), 2073, 2022
强制性开放获取政策： National Health and Medical Research Council, Australia, European Commission
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