| A protein interaction network of the malaria parasite Plasmodium falciparum DJ LaCount, M Vignali, R Chettier, A Phansalkar, R Bell, JR Hesselberth, ... Nature 438 (7064), 103-107, 2005 | 642 | 2005 |
| Huntingtin interacting proteins are genetic modifiers of neurodegeneration LS Kaltenbach, E Romero, RR Becklin, R Chettier, R Bell, A Phansalkar, ... PLoS genetics 3 (5), e82, 2007 | 531 | 2007 |
| Glucocorticoids suppress selected components of the senescence‐associated secretory phenotype RM Laberge, L Zhou, MR Sarantos, F Rodier, A Freund, PLJ de Keizer, ... Aging cell 11 (4), 569-578, 2012 | 243 | 2012 |
| Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease JP Miller, J Holcomb, I Al-Ramahi, M De Haro, J Gafni, N Zhang, E Kim, ... Neuron 67 (2), 199-212, 2010 | 208 | 2010 |
| Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm E Romero, GH Cha, P Verstreken, CV Ly, RE Hughes, HJ Bellen, J Botas Neuron 57 (1), 27-40, 2008 | 191 | 2008 |
| Systematic and large-scale two-hybrid screens P Uetz, RE Hughes Current opinion in microbiology 3 (3), 303-308, 2000 | 189 | 2000 |
| Proteomic analysis of age‐dependent changes in protein solubility identifies genes that modulate lifespan P Reis‐Rodrigues, G Czerwieniec, TW Peters, US Evani, S Alavez, ... Aging cell 11 (1), 120-127, 2012 | 188 | 2012 |
| Calcium binding, but not a calcium-myristoyl switch, controls the ability of guanylyl cyclase-activating protein GCAP-2 to regulate photoreceptor guanylyl cyclase EV Olshevskaya, RE Hughes, JB Hurley, AM Dizhoor Journal of Biological Chemistry 272 (22), 14327-14333, 1997 | 146 | 1997 |
| A human protein interaction network shows conservation of aging processes between human and invertebrate species R Bell, A Hubbard, R Chettier, D Chen, JP Miller, P Kapahi, ... PLoS genetics 5 (3), e1000414, 2009 | 144 | 2009 |
| Altered transcription in yeast expressing expanded polyglutamine RE Hughes, RS Lo, C Davis, AD Strand, CL Neal, JM Olson, S Fields Proceedings of the National Academy of Sciences 98 (23), 13201-13206, 2001 | 140 | 2001 |
| A Large Scale Huntingtin Protein Interaction Network Implicates Rho GTPase Signaling Pathways in Huntington Disease*♦ C Tourette, B Li, R Bell, S O'Hare, LS Kaltenbach, SD Mooney, ... Journal of Biological Chemistry 289 (10), 6709-6726, 2014 | 109 | 2014 |
| Cooperativity mutants of the γδ resolvase identify an essential interdimer interaction RE Hughes, GF Hatfull, P Rice, TA Steitz, NDF Grindley Cell 63 (6), 1331-1338, 1990 | 99 | 1990 |
| Therapeutic opportunities in polyglutamine disease RE Hughes, JM Olson Nature medicine 7 (4), 419-423, 2001 | 93 | 2001 |
| A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components C Gorbea, G Pratt, V Ustrell, R Bell, S Sahasrabudhe, RE Hughes, ... Journal of biological chemistry 285 (41), 31616-31633, 2010 | 86 | 2010 |
| Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening AL Orr, D Ashok, MR Sarantos, T Shi, RE Hughes, MD Brand Free Radical Biology and Medicine 65, 1047-1059, 2013 | 85 | 2013 |
| Protein‐protein interactions directing resolvase site‐specific recombination: a structure‐function analysis. RE Hughes, PA Rice, TA Steitz, ND Grindley The EMBO Journal 12 (4), 1447-1458, 1993 | 71 | 1993 |
| Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of rapamycin (mTOR) P Agrawal, YT Chen, B Schilling, BW Gibson, RE Hughes Journal of Biological Chemistry 287 (25), 21164-21175, 2012 | 67 | 2012 |
| Novel inhibitors of mitochondrial sn-glycerol 3-phosphate dehydrogenase AL Orr, D Ashok, MR Sarantos, R Ng, T Shi, AA Gerencser, RE Hughes, ... PLoS One 9 (2), e89938, 2014 | 60 | 2014 |
| Calcium-dependent solvation of the myristoyl group of recoverin RE Hughes, PS Brzovic, RE Klevit, JB Hurley Biochemistry 34 (36), 11410-11416, 1995 | 60 | 1995 |
| A genome-scale RNA–Interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease JP Miller, BE Yates, I Al-Ramahi, AE Berman, M Sanhueza, E Kim, ... PLoS genetics 8 (11), e1003042, 2012 | 53 | 2012 |
