| Regulating the p53 pathway: in vitro hypotheses, in vivo veritas F Toledo, GM Wahl Nature Reviews Cancer 6 (12), 909-923, 2006 | 1618 | 2006 |
| Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons A Coquelle, E Pipiras, F Toledo, G Buttin, M Debatisse Cell 89 (2), 215-225, 1997 | 474 | 1997 |
| Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4. JC Marine, S Francoz, M Maetens, G Wahl, F Toledo, G Lozano Cell Death & Differentiation 13 (6), 2006 | 454 | 2006 |
| MDM2 and MDM4: p53 regulators as targets in anticancer therapy F Toledo, GM Wahl The international journal of biochemistry & cell biology 39 (7-8), 1476-1482, 2007 | 343 | 2007 |
| A new role for hypoxia in tumor progression: induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs A Coquelle, F Toledo, S Stern, A Bieth, M Debatisse Molecular cell 2 (2), 259-265, 1998 | 286 | 1998 |
| A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network F Toledo, KA Krummel, CJ Lee, CW Liu, LW Rodewald, M Tang, GM Wahl Cancer cell 9 (4), 273-285, 2006 | 253 | 2006 |
| The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation KA Krummel, CJ Lee, F Toledo, GM Wahl Proceedings of the National Academy of Sciences 102 (29), 10188-10193, 2005 | 229 | 2005 |
| Co‐amplified markers alternate in megabase long chromosomal inverted repeats and cluster independently in interphase nuclei at early steps of mammalian gene amplification. F Toledo, D Le Roscouet, G Buttin, M Debatisse The EMBO journal 11 (7), 2665-2673, 1992 | 191 | 1992 |
| The guardian of the genome revisited: p53 downregulates genes required for telomere maintenance, DNA repair, and centromere structure E Toufektchan, F Toledo Cancers 10 (5), 135, 2018 | 170 | 2018 |
| Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression F Toledo, CJ Lee, KA Krummel, LW Rodewald, CW Liu, GM Wahl Molecular and cellular biology 27 (4), 1425-1432, 2007 | 104 | 2007 |
| Mutant Mice Lacking the p53 C-Terminal Domain Model Telomere Syndromes I Simeonova, S Jaber, I Draskovic, B Bardot, M Fang, R Bouarich-Bourimi, ... Cell reports 3, 2046-2058, 2013 | 95 | 2013 |
| The origin of chromosome rearrangements at early stages of AMPD2 gene amplification in Chinese hamster cells F Toledo, G Buttin, M Debatisse Current Biology 3 (5), 255-264, 1993 | 94 | 1993 |
| Gene amplification mechanisms: the role of fragile sites M Debatisse, A Coquelle, F Toledo, G Buttin Genes and Environment in Cancer, 216-226, 1998 | 78* | 1998 |
| Essential role for centromeric factors following p53 loss and oncogenic transformation D Filipescu, M Naughtin, K Podsypanina, V Lejour, L Wilson, ... Genes & development 31 (5), 463-480, 2017 | 70 | 2017 |
| p53 downregulates the Fanconi anaemia DNA repair pathway S Jaber, E Toufektchan, V Lejour, B Bardot, F Toledo Nature communications 7 (1), 11091, 2016 | 60 | 2016 |
| Germline mutation of MDM4, a major p53 regulator, in a familial syndrome of defective telomere maintenance E Toufektchan, V Lejour, R Durand, N Giri, I Draskovic, B Bardot, ... Science advances 6 (15), eaay3511, 2020 | 47 | 2020 |
| Ribosome biogenesis dysfunction leads to p53-mediated apoptosis and goblet cell differentiation of mouse intestinal stem/progenitor cells A Stedman, S Beck-Cormier, M Le Bouteiller, A Raveux, ... Cell Death & Differentiation 22 (11), 1865-1876, 2015 | 47 | 2015 |
| Amplification of the Adenylate-Deaminase 2 and Linked Genes in Chinese Hamster Lung Fibroblasts M Debatisse, F Toledo, BR De Saint Vincent, G Buttin Gene Amplification in Mammalian Cells, 173-184, 2020 | 45* | 2020 |
| Replication initiation in mammalian cells: changing preferences MI Debatisse, F Toledo, M Anglana Cell Cycle 3 (1), 18-20, 2004 | 43 | 2004 |
| oriGNAI3: A narrow zone of preferential replication initiation in mammalian cells identified by 2D gel and competitive PCR replicon mapping techniques F Toledo, B Baron, MA Fernandez, AM Lachagès, V Mayau, G Buttin, ... Nucleic acids research 26 (10), 2313-2321, 1998 | 43 | 1998 |
Geoff WahlProfessor, Gene Expression Lab, Salk Institute在 salk.edu 的电子邮件经过验证
