Using human genetics to understand the disease impacts of testosterone in men and women KS Ruth, FR Day, J Tyrrell, DJ Thompson, AR Wood, A Mahajan, ... Nature medicine 26 (2), 252-258, 2020 | 516 | 2020 |
Association of genetic variants related to gluteofemoral vs abdominal fat distribution with type 2 diabetes, coronary disease, and cardiovascular risk factors LA Lotta, LBL Wittemans, V Zuber, ID Stewart, SJ Sharp, J Luan, FR Day, ... Jama 320 (24), 2553-2563, 2018 | 189 | 2018 |
A cross-platform approach identifies genetic regulators of human metabolism and health LA Lotta, M Pietzner, ID Stewart, LBL Wittemans, C Li, R Bonelli, J Raffler, ... Nature genetics 53 (1), 54-64, 2021 | 139 | 2021 |
Assessing the causal association of glycine with risk of cardio-metabolic diseases LBL Wittemans, LA Lotta, C Oliver-Williams, ID Stewart, P Surendran, ... Nature communications 10 (1), 1060, 2019 | 118 | 2019 |
Obesity and risk of female reproductive conditions: A Mendelian randomisation study SS Venkatesh, T Ferreira, S Benonisdottir, N Rahmioglu, CM Becker, ... PLoS medicine 19 (2), e1003679, 2022 | 94 | 2022 |
Association of genetically enhanced lipoprotein lipase–mediated lipolysis and low-density lipoprotein cholesterol–lowering alleles with risk of coronary disease and type 2 diabetes LA Lotta, ID Stewart, SJ Sharp, FR Day, S Burgess, J Luan, N Bowker, ... JAMA cardiology 3 (10), 957-966, 2018 | 77 | 2018 |
Rare and common genetic determinants of metabolic individuality and their effects on human health P Surendran, ID Stewart, VPW Au Yeung, M Pietzner, J Raffler, ... Nature Medicine 28 (11), 2321-2332, 2022 | 69 | 2022 |
Insights into genetic variants associated with NASH-fibrosis from metabolite profiling JP Mann, M Pietzner, LB Wittemans, EDL Rolfe, ND Kerrison, F Imamura, ... Human molecular genetics 29 (20), 3451-3463, 2020 | 40 | 2020 |
Genetic studies of leptin concentrations implicate leptin in the regulation of early adiposity H Yaghootkar, Y Zhang, CN Spracklen, T Karaderi, LO Huang, J Bradfield, ... Diabetes 69 (12), 2806-2818, 2020 | 33 | 2020 |
Exome-derived adiponectin-associated variants implicate obesity and lipid biology CN Spracklen, T Karaderi, H Yaghootkar, C Schurmann, RS Fine, ... The American Journal of Human Genetics 105 (1), 15-28, 2019 | 27 | 2019 |
MicroRNA-196a links human body fat distribution to adipose tissue extracellular matrix composition C Hilton, MJ Neville, LBL Wittemans, M Todorcevic, KE Pinnick, SL Pulit, ... EBioMedicine 44, 467-475, 2019 | 25 | 2019 |
Evidence from men for ovary-independent effects of genetic risk factors for polycystic ovary syndrome J Zhu, N Pujol-Gualdo, LBL Wittemans, CM Lindgren, T Laisk, ... The Journal of Clinical Endocrinology & Metabolism 107 (4), e1577-e1587, 2022 | 22 | 2022 |
HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution FC Kuo, MJ Neville, R Sabaratnam, A Wesolowska-Andersen, D Phillips, ... Cell reports 40 (4), 2022 | 20 | 2022 |
Identification of rare loss-of-function genetic variation regulating body fat distribution M Koprulu, Y Zhao, E Wheeler, L Dong, N Rocha, C Li, JD Griffin, S Patel, ... The Journal of Clinical Endocrinology & Metabolism 107 (4), 1065-1077, 2022 | 17 | 2022 |
Cross-platform genetic discovery of small molecule products of metabolism and application to clinical outcomes LA Lotta, M Pietzner, ID Stewart, LBL Wittemans, C Li, R Bonelli, J Raffler, ... Nature genetics 53 (1), 54, 2021 | 13 | 2021 |
Regional fat depot masses are influenced by protein-coding gene variants MJ Neville, LBL Wittemans, KE Pinnick, M Todorčević, R Kaksonen, ... PloS one 14 (5), e0217644, 2019 | 13 | 2019 |
Endometrial Cancer Association C, McCarthy MI, Langenberg C, Easton DF, Wareham NJ, Burgess S, Murray A, Ong KK, Frayling TM, Perry JRB. Using human genetics to understand the … KS Ruth, FR Day, J Tyrrell, DJ Thompson, AR Wood, A Mahajan, ... Nat Med 26 (2), 252-258, 2020 | 12 | 2020 |
Prioritising risk factors for type 2 diabetes: causal inference through genetic approaches LBL Wittemans, LA Lotta, C Langenberg Current Diabetes Reports 18, 1-10, 2018 | 7 | 2018 |
A genetically defined male counterpart of polycystic ovary syndrome: Evidence for ovarian-independent pathogenesis J Zhu, LBL Wittemans, C Lindgren, JN Hirschhorn, YM Chan Journal of the Endocrine Society 5 (Suppl 1), A773, 2021 | 5 | 2021 |
Machine learning-based steroid metabolome analysis reveals three distinct subtypes of polycystic ovary syndrome and implicates 11-oxygenated androgens as major drivers of … E Melson, TP Rocha, RJ Veen, L Abdi, T Mcdonnell, V Tandl, JM Hawley, ... Endocrine Abstracts 90, 2023 | 3 | 2023 |