Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites LH Freitas-Junior, R Hernandez-Rivas, SA Ralph, D Montiel-Condado, ... Cell 121 (1), 25-36, 2005 | 562 | 2005 |
Genome-wide analysis of heterochromatin associates clonally variant gene regulation with perinuclear repressive centers in malaria parasites JJ Lopez-Rubio, L Mancio-Silva, A Scherf Cell host & microbe 5 (2), 179-190, 2009 | 391 | 2009 |
Sir2 Paralogues Cooperate to Regulate Virulence Genes and Antigenic Variation in Plasmodium falciparum CJ Tonkin, CK Carret, MT Duraisingh, TS Voss, SA Ralph, M Hommel, ... PLoS biology 7 (4), e1000084, 2009 | 290 | 2009 |
Plasmodium falciparum heterochromatin protein 1 binds to tri-methylated histone 3 lysine 9 and is linked to mutually exclusive expression of var genes K Perez-Toledo, AP Rojas-Meza, L Mancio-Silva, NA Hernandez-Cuevas, ... Nucleic acids research 37 (8), 2596-2606, 2009 | 189 | 2009 |
Nutrient sensing modulates malaria parasite virulence L Mancio-Silva, K Slavic, MT Grilo Ruivo, AR Grosso, KK Modrzynska, ... Nature 547 (7662), 213-216, 2017 | 158 | 2017 |
In vitro culture, drug sensitivity, and transcriptome of Plasmodium vivax hypnozoites N Gural, L Mancio-Silva, AB Miller, A Galstian, VL Butty, SS Levine, ... Cell host & microbe 23 (3), 395-406. e4, 2018 | 148 | 2018 |
B7–CD28 costimulatory signals control the survival and proliferation of murine and human γδ T cells via IL-2 production JC Ribot, A Debarros, L Mancio-Silva, A Pamplona, B Silva-Santos The Journal of Immunology 189 (3), 1202-1208, 2012 | 111 | 2012 |
A novel carbon monoxide-releasing molecule fully protects mice from severe malaria AC Pena, N Penacho, L Mancio-Silva, R Neres, JD Seixas, AC Fernandes, ... Antimicrobial agents and chemotherapy 56 (3), 1281-1290, 2012 | 111 | 2012 |
Plasmodium UIS3 sequesters host LC3 to avoid elimination by autophagy in hepatocytes E Real, L Rodrigues, GG Cabal, FJ Enguita, L Mancio-Silva, ... Nature microbiology 3 (1), 17-25, 2018 | 95 | 2018 |
Estrogen activation of G-protein–coupled estrogen receptor 1 regulates phosphoinositide 3-kinase and mTOR signaling to promote liver growth in zebrafish and proliferation of … S Chaturantabut, A Shwartz, KJ Evason, AG Cox, K Labella, AG Schepers, ... Gastroenterology 156 (6), 1788-1804. e13, 2019 | 90 | 2019 |
Differential association of Orc1 and Sir2 proteins to telomeric domains in Plasmodium falciparum L Mancio-Silva, AP Rojas-Meza, M Vargas, A Scherf, R Hernandez-Rivas Journal of cell science 121 (12), 2046-2053, 2008 | 90 | 2008 |
The unusually large Plasmodium telomerase reverse-transcriptase localizes in a discrete compartment associated with the nucleolus LM Figueiredo, EPC Rocha, L Mancio-Silva, C Prevost, ... Nucleic acids research 33 (3), 1111-1122, 2005 | 86 | 2005 |
Steroid hormone function controls non-competitive Plasmodium development in Anopheles K Werling, WR Shaw, MA Itoe, KA Westervelt, P Marcenac, DG Paton, ... Cell 177 (2), 315-325. e14, 2019 | 81 | 2019 |
GLUT1‐mediated glucose uptake plays a crucial role during Plasmodium hepatic infection P Meireles, J Sales‐Dias, CM Andrade, J Mello‐Vieira, L Mancio‐Silva, ... Cellular microbiology 19 (2), e12646, 2017 | 77 | 2017 |
Two long non-coding RNAs generated from subtelomeric regions accumulate in a novel perinuclear compartment in Plasmodium falciparum M Sierra-Miranda, DM Delgadillo, L Mancio-Silva, M Vargas, ... Molecular and biochemical parasitology 185 (1), 36-47, 2012 | 64 | 2012 |
Sir2a regulates rDNA transcription and multiplication rate in the human malaria parasite Plasmodium falciparum L Mancio-Silva, JJ Lopez-Rubio, A Claes, A Scherf Nature communications 4 (1), 1530, 2013 | 61 | 2013 |
Expansion, in vivo–ex vivo cycling, and genetic manipulation of primary human hepatocytes E Michailidis, K Vercauteren, L Mancio-Silva, L Andrus, C Jahan, ... Proceedings of the National Academy of Sciences 117 (3), 1678-1688, 2020 | 51 | 2020 |
Engineered livers for infectious diseases N Gural, L Mancio-Silva, J He, SN Bhatia Cellular and molecular gastroenterology and hepatology 5 (2), 131-144, 2018 | 48 | 2018 |
Host AMPK is a modulator of Plasmodium liver infection MTG Ruivo, IM Vera, J Sales-Dias, P Meireles, N Gural, SN Bhatia, ... Cell reports 16 (10), 2539-2545, 2016 | 44 | 2016 |
Differential sub-nuclear localisation of repressive and activating histone methyl modifications in P. falciparum N Issar, SA Ralph, L Mancio-Silva, C Keeling, A Scherf Microbes and infection 11 (3), 403-407, 2009 | 41 | 2009 |