De novo design of protein homo-oligomers with modular hydrogen-bond network–mediated specificity SE Boyken, Z Chen, B Groves, RA Langan, G Oberdorfer, A Ford, ... Science 352 (6286), 680-687, 2016 | 365 | 2016 |
De novo design of bioactive protein switches RA Langan, SE Boyken, AH Ng, JA Samson, G Dods, AM Westbrook, ... Nature 572 (7768), 205-210, 2019 | 262 | 2019 |
De novo design of modular and tunable protein biosensors A Quijano-Rubio, HW Yeh, J Park, H Lee, RA Langan, SE Boyken, ... Nature 591 (7850), 482-487, 2021 | 190 | 2021 |
Programmable design of orthogonal protein heterodimers Z Chen, SE Boyken, M Jia, F Busch, D Flores-Solis, MJ Bick, P Lu, ... Nature 565 (7737), 106-111, 2019 | 183 | 2019 |
Designed protein logic to target cells with precise combinations of surface antigens MJ Lajoie, SE Boyken, AI Salter, J Bruffey, A Rajan, RA Langan, ... Science 369 (6511), 1637-1643, 2020 | 155 | 2020 |
Modular and tunable biological feedback control using a de novo protein switch AH Ng, TH Nguyen, M Gómez-Schiavon, G Dods, RA Langan, SE Boyken, ... Nature 572 (7768), 265-269, 2019 | 112 | 2019 |
Generation of ordered protein assemblies using rigid three-body fusion I Vulovic, Q Yao, YJ Park, A Courbet, A Norris, F Busch, A Sahasrabuddhe, ... Proceedings of the National Academy of Sciences 118 (23), e2015037118, 2021 | 38 | 2021 |
Conditional Recruitment to a DNA-Bound CRISPR–Cas Complex Using a Colocalization-Dependent Protein Switch RL Kirkpatrick, K Lewis, RA Langan, MJ Lajoie, SE Boyken, M Eakman, ... ACS synthetic biology 9 (9), 2316-2323, 2020 | 10 | 2020 |
De novo design of modular and tunable allosteric biosensors A Quijano-Rubio, HW Yeh, J Park, H Lee, RA Langan, SE Boyken, ... bioRxiv, 2020.07. 18.206946, 2020 | 7 | 2020 |
Publisher Correction: Modular and tunable biological feedback control using a de novo protein switch AH Ng, TH Nguyen, M Gómez-Schiavon, G Dods, RA Langan, SE Boyken, ... Nature 579 (7798), E8, 2020 | 3 | 2020 |
De novo design of protein switches RA Langan, S Boyken, D Baker, W Novak, MJ Lajoie, AQ RUBIO US Patent 10,851,135, 2020 | 2 | 2020 |
Orthogonal protein heterodimers C Zibo, S Boyken, S Bermeo, RA Langan, D Baker US Patent 11,820,800, 2023 | 1 | 2023 |
De novo design of phosphorylation inducible protein switches (phospho-switches) N Woodall, S Boyken, MJ Lajoie, C Zibo, RA Langan, D Baker US Patent App. 17/618,117, 2022 | 1 | 2022 |
Caged-degron-based molecular feedback circuits and methods of using the same D Baker, S Boyken, ELS Hana, M Lajoie, R Langan, A Ng US Patent App. 17/419,236, 2022 | 1 | 2022 |
Orthogonal protein heterodimers C Zibo, S Boyken, S Bermeo, RA Langan, D Baker US Patent App. 17/502,485, 2022 | 1 | 2022 |
De novo design of protein switches for tunable control of protein degradation R Langan, A Ng, S Boyken, M Lajoie, ELS Hana, D Baker US Patent App. 17/419,413, 2022 | 1 | 2022 |
heterodimers Z Chen, SE Boyken, M Jia, F Busch, D Flores-solis, MJ Bick, P Lu, ... Springer US, 2019 | 1 | 2019 |
De Novo Design of Bioactive Protein Switches, and Applications Thereof RA Langan | 1 | 2019 |
Orthogonal protein heterodimers C Zibo, S Boyken, S Bermeo, RA Langan, D Baker US Patent App. 18/158,384, 2024 | | 2024 |
OPB-101: An optimized mesothelin-specific CAR T cell product expressing CD8-targeted IL-2/15 and engineered to resist T cell exhaustion R Amin, H Moffett, K Haworth, J Chen, J Yokoyama, A Wang, L Tait, ... Cancer Research 84 (6_Supplement), 51-51, 2024 | | 2024 |