Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites M Dawidowski, L Emmanouilidis, VC Kalel, K Tripsianes, K Schorpp, ... Science 355 (6332), 1416-1420, 2017 | 85 | 2017 |
Molecular basis of peroxisomal biogenesis disorders caused by defects in peroxisomal matrix protein import S Nagotu, VC Kalel, R Erdmann, HW Platta Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1822 (9 …, 2012 | 44 | 2012 |
Identification and functional characterization of Trypanosoma brucei peroxin 16 VC Kalel, W Schliebs, R Erdmann Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1853 (10), 2326-2337, 2015 | 32 | 2015 |
COVID-19, neuropathology, and aging: SARS-CoV-2 neurological infection, mechanism, and associated complications RS Kalra, JK Dhanjal, AS Meena, VC Kalel, S Dahiya, B Singh, ... Frontiers in Aging Neuroscience 13, 662786, 2021 | 28 | 2021 |
Structure–Activity Relationship in Pyrazolo[4,3-c]pyridines, First Inhibitors of PEX14–PEX5 Protein–Protein Interaction with Trypanocidal Activity M Dawidowski, VC Kalel, V Napolitano, R Fino, K Schorpp, ... Journal of medicinal chemistry 63 (2), 847-879, 2019 | 23 | 2019 |
Evolutionary divergent PEX3 is essential for glycosome biogenesis and survival of trypanosomatid parasites VC Kalel, M Li, S Gaussmann, F Delhommel, AB Schaefer, B Tippler, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1866 (12), 118520, 2019 | 18 | 2019 |
Unraveling of the structure and function of peroxisomal protein import machineries VC Kalel, R Erdmann Proteomics of Peroxisomes: Identifying Novel Functions and Regulatory …, 2018 | 18 | 2018 |
Come, sweet death: Targeting glycosomal protein import for antitrypanosomal drug development VC Kalel, P Mäser, M Sattler, R Erdmann, GM Popowicz Current opinion in microbiology 46, 116-122, 2018 | 16 | 2018 |
Inhibitors of glycosomal protein import provide new leads against trypanosomiasis VC Kalel, L Emmanouilidis, M Dawidowski, W Schliebs, M Sattler, ... Microbial Cell 4 (7), 229, 2017 | 15 | 2017 |
Novel trypanocidal inhibitors that block glycosome biogenesis by targeting PEX3–PEX19 interaction M Li, S Gaussmann, B Tippler, J Ott, GM Popowicz, W Schliebs, M Sattler, ... Frontiers in Cell and Developmental Biology 9, 737159, 2021 | 6 | 2021 |
Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma V Napolitano, P Mróz, M Marciniak, VC Kalel, CA Softley, JDJ Olmos, ... European Journal of Medicinal Chemistry 243, 114778, 2022 | 5 | 2022 |
Computer-aided design and synthesis of a new class of PEX14 inhibitors: substituted 2, 3, 4, 5-tetrahydrobenzo [F][1, 4] oxazepines as potential new trypanocidal agents R Fino, D Lenhart, VC Kalel, CA Softley, V Napolitano, R Byrne, ... Journal of Chemical Information and Modeling 61 (10), 5256-5268, 2021 | 5 | 2021 |
Current advances in the function and biogenesis of peroxisomes and their roles in health and disease N Dahan, T Francisco, C Falter, T Rodrigues, V Kalel, M Kunze, T Hansen, ... Histochemistry and cell biology 155, 513-524, 2021 | 5 | 2021 |
Development of novel PEX5-PEX14 protein-protein interaction (PPI) inhibitors based on an oxopiperazine template M Marciniak, P Mróz, V Napolitano, VC Kalel, R Fino, E Pykacz, ... European Journal of Medicinal Chemistry 258, 115587, 2023 | 4 | 2023 |
Small molecule mediated inhibition of protein cargo recognition by peroxisomal transport receptor PEX5 is toxic to Trypanosoma V Napolitano, CA Softley, A Blat, VC Kalel, K Schorpp, T Siebenmorgen, ... Scientific Reports 12 (1), 14705, 2022 | 3 | 2022 |
Isolation of Glycosomes from Trypanosoma brucei CK Krishna, L Franke, R Erdmann, VC Kalel Peroxisomes: Methods and protocols, 33-45, 2023 | 2 | 2023 |
Functional Analyses of a Putative, Membrane-Bound, Peroxisomal Protein Import Mechanism from the Apicomplexan Protozoan Toxoplasma gondii AJ Mbekeani, WA Stanley, VC Kalel, N Dahan, E Zalckvar, L Sheiner, ... Genes 9 (9), 434, 2018 | 2 | 2018 |
Biochemical Fractionation of Trypanosomes for the Analysis of Glycosomal Protein Import Defects SE Chou, VC Kalel, R Erdmann Peroxisomes: Methods and Protocols, 445-453, 2023 | 1 | 2023 |
High confidence glycosomal membrane protein inventory unveils trypanosomal Peroxin PEX15 CK Krishna, H Das, L Hohnen, W Schliebs, S Oeljeklaus, B Warscheid, ... bioRxiv, 2023.10. 13.562043, 2023 | 1 | 2023 |
Pyrazolopyridine derivatives and their use in therapy M Sattler, G Popowicz, M Dawidowski, L Emmanouilidis, R Erdmann, ... US Patent 10,138,242, 2018 | 1 | 2018 |