Finding the end: recruitment of telomerase to telomeres J Nandakumar, TR Cech Nature reviews Molecular cell biology 14 (2), 69-82, 2013 | 438 | 2013 |
The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity J Nandakumar, CF Bell, I Weidenfeld, AJ Zaug, LA Leinwand, TR Cech Nature 492 (7428), 285-289, 2012 | 396 | 2012 |
Structural biology of telomeres and telomerase EM Smith, DF Pendlebury, J Nandakumar Cellular and Molecular Life Sciences 77, 61-79, 2020 | 170 | 2020 |
Functional interaction between telomere protein TPP1 and telomerase AJ Zaug, ER Podell, J Nandakumar, TR Cech Genes & development 24 (6), 613-622, 2010 | 167 | 2010 |
Hoyeraal-Hreidarsson syndrome caused by a germline mutation in the TEL patch of the telomere protein TPP1 H Kocak, BJ Ballew, K Bisht, R Eggebeen, BD Hicks, S Suman, A O’Neil, ... Genes & development 28 (19), 2090-2102, 2014 | 142 | 2014 |
RNA substrate specificity and structure-guided mutational analysis of bacteriophage T4 RNA ligase 2 J Nandakumar, CK Ho, CD Lima, S Shuman Journal of Biological Chemistry 279 (30), 31337-31347, 2004 | 111 | 2004 |
Last stop on the road to repair: structure of E. coli DNA ligase bound to nicked DNA-adenylate J Nandakumar, PA Nair, S Shuman Molecular cell 26 (2), 257-271, 2007 | 107 | 2007 |
RNA ligase structures reveal the basis for RNA specificity and conformational changes that drive ligation forward J Nandakumar, S Shuman, CD Lima Cell 127 (1), 71-84, 2006 | 101 | 2006 |
How an RNA ligase discriminates RNA versus DNA damage J Nandakumar, S Shuman Molecular cell 16 (2), 211-221, 2004 | 96 | 2004 |
Structural basis for nick recognition by a minimal pluripotent DNA ligase PA Nair, J Nandakumar, P Smith, M Odell, CD Lima, S Shuman Nature structural & molecular biology 14 (8), 770-778, 2007 | 93 | 2007 |
RNA repair: an antidote to cytotoxic eukaryal RNA damage J Nandakumar, B Schwer, R Schaffrath, S Shuman Molecular cell 31 (2), 278-286, 2008 | 91 | 2008 |
Molecular mechanisms of telomere biology disorders S Grill, J Nandakumar Journal of Biological Chemistry 296, 2021 | 80 | 2021 |
How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA J Nandakumar, ER Podell, TR Cech Proceedings of the National Academy of Sciences 107 (2), 651-656, 2010 | 77 | 2010 |
Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D H Zhu, J Nandakumar, J Aniukwu, LK Wang, MS Glickman, CD Lima, ... Proceedings of the National Academy of Sciences 103 (6), 1711-1716, 2006 | 74 | 2006 |
Pot1 OB-fold mutations unleash telomere instability to initiate tumorigenesis P Gu, Y Wang, KK Bisht, L Wu, L Kukova, EM Smith, Y Xiao, SM Bailey, ... Oncogene 36 (14), 1939-1951, 2017 | 59 | 2017 |
Inhibition of telomerase recruitment and cancer cell death M Nakashima, J Nandakumar, KD Sullivan, JM Espinosa, TR Cech Journal of Biological Chemistry 288 (46), 33171-33180, 2013 | 59 | 2013 |
The shelterin complex and hematopoiesis M Jones, K Bisht, SA Savage, J Nandakumar, CE Keegan, I Maillard The Journal of clinical investigation 126 (5), 1621-1629, 2016 | 52 | 2016 |
The N terminus of the OB domain of telomere protein TPP1 is critical for telomerase action S Grill, VM Tesmer, J Nandakumar Cell reports 22 (5), 1132-1140, 2018 | 51 | 2018 |
The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells J Zhang, M Gurusaran, Y Fujiwara, K Zhang, M Echbarthi, E Vorontsov, ... Nature communications 11 (1), 2055, 2020 | 49 | 2020 |
Structural and functional consequences of a disease mutation in the telomere protein TPP1 K Bisht, EM Smith, VM Tesmer, J Nandakumar Proceedings of the National Academy of Sciences 113 (46), 13021-13026, 2016 | 46 | 2016 |