FKBP12. 6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death XHT Wehrens, SE Lehnart, F Huang, JA Vest, SR Reiken, PJ Mohler, ... Cell 113 (7), 829-840, 2003 | 911 | 2003 |
Impact of noncardiac comorbidities on morbidity and mortality in a predominantly male population with heart failure and preserved versus reduced ejection fraction S Ather, W Chan, B Bozkurt, D Aguilar, K Ramasubbu, AA Zachariah, ... Journal of the American College of Cardiology 59 (11), 998-1005, 2012 | 823 | 2012 |
Ca2+/Calmodulin-Dependent Protein Kinase II Phosphorylation Regulates the Cardiac Ryanodine Receptor XHT Wehrens, SE Lehnart, SR Reiken, AR Marks Circulation research 94 (6), e61-e70, 2004 | 800 | 2004 |
Enhanced Sarcoplasmic Reticulum Ca2+ Leak and Increased Na+-Ca2+ Exchanger Function Underlie Delayed Afterdepolarizations in Patients With Chronic … N Voigt, N Li, Q Wang, W Wang, AW Trafford, I Abu-Taha, Q Sun, ... Circulation 125 (17), 2059-2070, 2012 | 673 | 2012 |
Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias SE Lehnart, XHT Wehrens, S Reiken, S Warrier, AE Belevych, RD Harvey, ... Cell 123 (1), 25-35, 2005 | 601 | 2005 |
Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2 XHT Wehrens, SE Lehnart, SR Reiken, SX Deng, JA Vest, D Cervantes, ... Science 304 (5668), 292-296, 2004 | 589 | 2004 |
Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation N Voigt, J Heijman, Q Wang, DY Chiang, N Li, M Karck, XHT Wehrens, ... Circulation 129 (2), 145-156, 2014 | 522 | 2014 |
Calcium signaling and cardiac arrhythmias AP Landstrom, D Dobrev, XHT Wehrens Circulation research 120 (12), 1969-1993, 2017 | 515 | 2017 |
Evidence for multiple mechanisms in human ventricular fibrillation MP Nash, A Mourad, RH Clayton, PM Sutton, CP Bradley, M Hayward, ... Circulation 114 (6), 536-542, 2006 | 478* | 2006 |
Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation C Yao, T Veleva, L Scott Jr, S Cao, L Li, G Chen, P Jeyabal, X Pan, ... Circulation 138 (20), 2227-2242, 2018 | 475 | 2018 |
Calmodulin kinase II–mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice MG Chelu, S Sarma, S Sood, S Wang, RJ Van Oort, DG Skapura, N Li, ... The Journal of clinical investigation 119 (7), 1940-1951, 2009 | 466 | 2009 |
Intracellular calcium release and cardiac disease XHT Wehrens, SE Lehnart, AR Marks Annu. Rev. Physiol. 67, 69-98, 2005 | 436 | 2005 |
Defective cardiac ryanodine receptor regulation during atrial fibrillation JA Vest, XHT Wehrens, SR Reiken, SE Lehnart, D Dobrev, P Chandra, ... Circulation 111 (16), 2025-2032, 2005 | 434 | 2005 |
β-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure S Reiken, XHT Wehrens, JA Vest, A Barbone, S Klotz, D Mancini, ... Circulation 107 (19), 2459-2466, 2003 | 418 | 2003 |
Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression XHT Wehrens, SE Lehnart, S Reiken, JA Vest, A Wronska, AR Marks Proceedings of the National Academy of Sciences 103 (3), 511-518, 2006 | 414 | 2006 |
Circadian rhythms govern cardiac repolarization and arrhythmogenesis D Jeyaraj, SM Haldar, X Wan, MD McCauley, JA Ripperger, K Hu, Y Lu, ... Nature 483 (7387), 96-99, 2012 | 400 | 2012 |
Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak SE Lehnart, XHT Wehrens, PJ Laitinen, SR Reiken, SX Deng, Z Cheng, ... Circulation 109 (25), 3208-3214, 2004 | 383 | 2004 |
Transverse aortic constriction in mice AC deAlmeida, RJ van Oort, XHT Wehrens JoVE (Journal of Visualized Experiments), e1729, 2010 | 366 | 2010 |
Evidence for multiple mechanisms in human ventricular fibrillation MP Nash, A Mourad, RH Clayton, PM Sutton, CP Bradley, M Hayward, ... Circulation 114 (6), 536-542, 2006 | 347 | 2006 |
Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure RJ Van Oort, MD McCauley, SS Dixit, L Pereira, Y Yang, JL Respress, ... Circulation 122 (25), 2669-2679, 2010 | 342 | 2010 |