作者
Guo Wang, He-Ping Lei, Zhi Li, Zhi-Rong Tan, Dong Guo, Lan Fan, Yao Chen, Dong-Li Hu, Dan Wang, Hong-Hao Zhou
发表日期
2009/3
期刊
European journal of clinical pharmacology
卷号
65
页码范围
281-285
出版商
Springer-Verlag
简介
Aim
To study the pharmacokinetic characteristics of voriconazole in healthy Chinese male volunteers in relation to cytochrome P450 (CYP) 2C19 genotype status, including ultra-rapid metabolizers (URMs), homozygous extensive metabolizers (EMs), and poor metabolizers (PMs).
Method
Twenty healthy Chinese male volunteers were recruited for the study. Of these, four were CYP2C19 heterozygous URMs (*1/*17), eight were CYP2C19 homozygous EMs (*1/*1), and eight were CYP2C19 PMs (*2/*2). After a single oral dose of 200 mg voriconazole, plasma concentrations of voriconazole were determined for a 24-h period by liquid chromatography–mass spectrometry/mass spectrometry.
Result
In Chinese male subjects, the allele frequencies of the CYP2C19*17 and CYP2C19*2 alleles were 0.64 and 35.6 …
引用总数
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G Wang, HP Lei, Z Li, ZR Tan, D Guo, L Fan, Y Chen… - European journal of clinical pharmacology, 2009