作者
Jonathan RI Coleman, Wouter J Peyrot, Kirstin L Purves, Katrina AS Davis, Christopher Rayner, Shing Wan Choi, Christopher Hübel, Héléna A Gaspar, Carol Kan, Sandra Van der Auwera, Mark James Adams, Donald M Lyall, Karmel W Choi, Erin C Dunn, Evangelos Vassos, Andrea Danese, Barbara Maughan, Hans J Grabe, Cathryn M Lewis, Paul F O’Reilly, Andrew M McIntosh, Daniel J Smith, Naomi R Wray, Matthew Hotopf, Thalia C Eley, Gerome Breen
发表日期
2020/7/1
期刊
Molecular psychiatry
卷号
25
期号
7
页码范围
1430-1446
出版商
Nature Publishing Group UK
简介
Depression is more frequent among individuals exposed to traumatic events. Both trauma exposure and depression are heritable. However, the relationship between these traits, including the role of genetic risk factors, is complex and poorly understood. When modelling trauma exposure as an environmental influence on depression, both gene-environment correlations and gene-environment interactions have been observed. The UK Biobank concurrently assessed Major Depressive Disorder (MDD) and self-reported lifetime exposure to traumatic events in 126,522 genotyped individuals of European ancestry. We contrasted genetic influences on MDD stratified by reported trauma exposure (final sample size range: 24,094–92,957). The SNP-based heritability of MDD with reported trauma exposure (24%) was greater than MDD without reported trauma exposure (12%). Simulations showed that this is not …
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JRI Coleman, WJ Peyrot, KL Purves, KAS Davis… - Molecular psychiatry, 2020