作者
Sꎬ Steinberg, Ole Mors, AD Børglum, O Gustafsson, Thomas Werge, PB Mortensen, OA Andreassen, E Sigurdsson, TE Thorgeirsson, Y Böttcher, P Olason, RA Ophoff, S Cichon, IH Gudjonsdottir, OPH Pietiläinen, Mette Nyegaard, A Tuulio-Henriksson, A Ingason, T Hansen, L Athanasiu, J Suvisaari, J Lonnqvist, T Paunio, A Hartmann, G Jürgens, M Nordentoft, D Hougaard, B Norgaard-Pedersen, R Breuer, HJ Möller, I Giegling, B Glenthøj, HB Rasmussen, M Mattheisen, I Bitter, JM Rethelyi, T Sigmundsson, R Fossdal, U Thorsteinsdottir, Mirella Ruggeri, Sarah Tosato, E Strengman, LA Kiemeney, I Melle, S Djurovic, L Abramova, V Kaleda, M Walshe, E Bramon, Evangelos Vassos, T Li, G Fraser, N Walker, T Toulopoulou, J Yoon, NB Freimer, RM Cantor, R Murray, A Kong, V Golimbet, EG Jönsson, L Terenius, I Agartz, H Petursson, MM Nöthen, M Rietschel, L Peltonen, D Rujescu, DA Collier, H Stefansson, D St Clair, K Stefansson
发表日期
2011/1
期刊
Molecular psychiatry
卷号
16
期号
1
页码范围
59-66
出版商
Nature Publishing Group
简介
A trio of genome-wide association studies recently reported sequence variants at three loci to be significantly associated with schizophrenia. No sequence polymorphism had been unequivocally (P< 5× 10− 8) associated with schizophrenia earlier. However, one variant, rs1344706 [T], had come very close. This polymorphism, located in an intron of ZNF804A, was reported to associate with schizophrenia with a P-value of 1.6× 10− 7, and with psychosis (schizophrenia plus bipolar disorder) with a P-value of 1.0× 10− 8. In this study, using 5164 schizophrenia cases and 20 709 controls, we replicated the association with schizophrenia (odds ratio OR= 1.08, P= 0.0029) and, by adding bipolar disorder patients, we also confirmed the association with psychosis (added N= 609, OR= 1.09, P= 0.00065). Furthermore, as it has been proposed that variants such as rs1344706 [T]—common and with low relative risk—may …
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S Steinberg, O Mors, AD Børglum, O Gustafsson… - Molecular psychiatry, 2011