作者
Zhaozhong Zhu, Yanjun Guo, Huwenbo Shi, Cong-Lin Liu, Ronald Allan Panganiban, Wonil Chung, Luke J O'Connor, Blanca E Himes, Steven Gazal, Kohei Hasegawa, Carlos A Camargo Jr, Lu Qi, Miriam F Moffatt, Frank B Hu, Quan Lu, William OC Cookson, Liming Liang
发表日期
2020/2/1
期刊
Journal of Allergy and Clinical Immunology
卷号
145
期号
2
页码范围
537-549
出版商
Mosby
简介
Background
Clinical and epidemiologic studies have shown that obesity is associated with asthma and that these associations differ by asthma subtype. Little is known about the shared genetic components between obesity and asthma.
Objective
We sought to identify shared genetic associations between obesity-related traits and asthma subtypes in adults.
Methods
A cross-trait genome-wide association study (GWAS) was performed using 457,822 subjects of European ancestry from the UK Biobank. Experimental evidence to support the role of genes significantly associated with both obesity-related traits and asthma through a GWAS was sought by using results from obese versus lean mouse RNA sequencing and RT-PCR experiments.
Results
We found a substantial positive genetic correlation between body mass index and later-onset asthma defined by asthma age of onset at 16 years or greater (Rg = 0.25, P = 9 …
学术搜索中的文章
Z Zhu, Y Guo, H Shi, CL Liu, RA Panganiban, W Chung… - Journal of Allergy and Clinical Immunology, 2020