作者
VT Nguyen, A Braun, J Kraft, TMT Ta, GM Panagiotaropoulou, VP Nguyen, TH Nguyen, V Trubetskoy, CT Le, TTH Le, XT Pham, I Heuser-Collier, NH Lam, K Böge, IM Hahne, M Bajbouj, MM Zierhut, E Hahn, S Ripke
发表日期
2022/3/16
期刊
The World Journal of Biological Psychiatry
卷号
23
期号
3
页码范围
219-227
出版商
Taylor & Francis
简介
Objectives
Genome-Wide Association Studies (GWAS) of Schizophrenia (SCZ) have provided new biological insights; however, most cohorts are of European ancestry. As a result, derived polygenic risk scores (PRS) show decreased predictive power when applied to populations of different ancestries. We aimed to assess the feasibility of a large-scale data collection in Hanoi, Vietnam, contribute to international efforts to diversify ancestry in SCZ genetic research and examine the transferability of SCZ-PRS to individuals of Vietnamese Kinh ancestry.
Methods
In a pilot study, 368 individuals (including 190 SCZ cases) were recruited at the Hanoi Medical University's associated psychiatric hospitals and outpatient facilities. Data collection included sociodemographic data, baseline clinical data, clinical interviews assessing symptom severity and genome-wide SNP genotyping. SCZ-PRS were generated using different …
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VT Nguyen, A Braun, J Kraft, TMT Ta… - The World Journal of Biological Psychiatry, 2022