作者
Ming-Huei Chen, Laura M Raffield, Abdou Mousas, Saori Sakaue, Jennifer E Huffman, Arden Moscati, Bhavi Trivedi, Tao Jiang, Parsa Akbari, Dragana Vuckovic, Erik L Bao, Xue Zhong, Regina Manansala, Véronique Laplante, Minhui Chen, Ken Sin Lo, Huijun Qian, Caleb A Lareau, Mélissa Beaudoin, Karen A Hunt, Masato Akiyama, Traci M Bartz, Yoav Ben-Shlomo, Andrew Beswick, Jette Bork-Jensen, Erwin P Bottinger, Jennifer A Brody, Frank JA van Rooij, Kumaraswamynaidu Chitrala, Kelly Cho, Hélène Choquet, Adolfo Correa, John Danesh, Emanuele Di Angelantonio, Niki Dimou, Jingzhong Ding, Paul Elliott, Tõnu Esko, Michele K Evans, James S Floyd, Linda Broer, Niels Grarup, Michael H Guo, Andreas Greinacher, Jeff Haessler, Torben Hansen, Joanna MM Howson, Qin Qin Huang, Wei Huang, Eric Jorgenson, Tim Kacprowski, Mika Kähönen, Yoichiro Kamatani, Masahiro Kanai, Savita Karthikeyan, Fotis Koskeridis, Leslie A Lange, Terho Lehtimäki, Markus M Lerch, Allan Linneberg, Yongmei Liu, Leo-Pekka Lyytikäinen, Ani Manichaikul, Hilary C Martin, Koichi Matsuda, Karen L Mohlke, Nina Mononen, Yoshinori Murakami, Girish N Nadkarni, Matthias Nauck, Kjell Nikus, Willem H Ouwehand, Nathan Pankratz, Oluf Pedersen, Michael Preuss, Bruce M Psaty, Olli T Raitakari, David J Roberts, Stephen S Rich, Benjamin AT Rodriguez, Jonathan D Rosen, Jerome I Rotter, Petra Schubert, Cassandra N Spracklen, Praveen Surendran, Hua Tang, Jean-Claude Tardif, Richard C Trembath, Mohsen Ghanbari, Uwe Völker, Henry Völzke, Nicholas A Watkins, Alan B Zonderman, VA Million Veteran Program, Peter WF Wilson, Yun Li, Adam S Butterworth, Jean-François Gauchat, Charleston WK Chiang, Bingshan Li, Ruth JF Loos, William J Astle, Evangelos Evangelou, David A van Heel, Vijay G Sankaran, Yukinori Okada, Nicole Soranzo, Andrew D Johnson, Alexander P Reiner, Paul L Auer, Guillaume Lettre
发表日期
2020/9/3
期刊
Cell
卷号
182
期号
5
页码范围
1198-1213. e14
出版商
Cell Press
简介
Most loci identified by GWASs have been found in populations of European ancestry (EUR). In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including 184,535 non-EUR individuals, we identified 5,552 trait-variant associations at p < 5 × 10−9, including 71 novel associations not found in EUR populations. We also identified 28 additional novel variants in ancestry-specific, non-EUR meta-analyses, including an IL7 missense variant in South Asians associated with lymphocyte count in vivo and IL-7 secretion levels in vitro. Fine-mapping prioritized variants annotated as functional and generated 95% credible sets that were 30% smaller when using the trans-ethnic as opposed to the EUR-only results. We explored the clinical significance and predictive value of trans-ethnic variants in multiple populations and compared genetic architecture and the effect of natural selection on these …
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MH Chen, LM Raffield, A Mousas, S Sakaue… - Cell, 2020