作者
Matthias Wuttke, Yong Li, Man Li, Karsten B Sieber, Mary F Feitosa, Mathias Gorski, Adrienne Tin, Lihua Wang, Audrey Y Chu, Anselm Hoppmann, Holger Kirsten, Ayush Giri, Jin-Fang Chai, Gardar Sveinbjornsson, Bamidele O Tayo, Teresa Nutile, Christian Fuchsberger, Jonathan Marten, Massimiliano Cocca, Sahar Ghasemi, Yizhe Xu, Katrin Horn, Damia Noce, Peter J van der Most, Sanaz Sedaghat, Zhi Yu, Masato Akiyama, Saima Afaq, Tarunveer S Ahluwalia, Peter Almgren, Najaf Amin, Johan Ärnlöv, Stephan JL Bakker, Nisha Bansal, Daniela Baptista, Sven Bergmann, Mary L Biggs, Ginevra Biino, Michael Boehnke, Eric Boerwinkle, Mathilde Boissel, Erwin P Bottinger, Thibaud S Boutin, Hermann Brenner, Marco Brumat, Ralph Burkhardt, Adam S Butterworth, Eric Campana, Archie Campbell, Harry Campbell, Mickaël Canouil, Robert J Carroll, Eulalia Catamo, John C Chambers, Miao-Ling Chee, Miao-Li Chee, Xu Chen, Ching-Yu Cheng, Yurong Cheng, Kaare Christensen, Renata Cifkova, Marina Ciullo, Maria Pina Concas, James P Cook, Josef Coresh, Tanguy Corre, Cinzia Felicita Sala, Daniele Cusi, John Danesh, E Warwick Daw, Martin H de Borst, Alessandro De Grandi, Renée de Mutsert, Aiko PJ de Vries, Frauke Degenhardt, Graciela Delgado, Ayse Demirkan, Emanuele Di Angelantonio, Katalin Dittrich, Jasmin Divers, Rajkumar Dorajoo, Kai-Uwe Eckardt, Georg Ehret, Paul Elliott, Karlhans Endlich, Michele K Evans, Janine F Felix, Valencia Hui Xian Foo, Oscar H Franco, Andre Franke, Barry I Freedman, Sandra Freitag-Wolf, Yechiel Friedlander, Philippe Froguel, Ron T Gansevoort, He Gao, Paolo Gasparini, J Michael Gaziano, Vilmantas Giedraitis, Christian Gieger, Giorgia Girotto, Franco Giulianini, Martin Gögele, Scott D Gordon, Daniel F Gudbjartsson, Vilmundur Gudnason, Toomas Haller, Pavel Hamet, Tamara B Harris, Catharina A Hartman, Caroline Hayward, Jacklyn N Hellwege, Chew-Kiat Heng, Andrew A Hicks, Edith Hofer, Wei Huang, Nina Hutri-Kähönen, Shih-Jen Hwang, M Arfan Ikram, Olafur S Indridason, Erik Ingelsson, Marcus Ising, Vincent WV Jaddoe, Johanna Jakobsdottir, Jost B Jonas, Peter K Joshi, Navya Shilpa Josyula, Bettina Jung, Mika Kähönen, Yoichiro Kamatani, Candace M Kammerer, Masahiro Kanai, Mika Kastarinen, Shona M Kerr, Chiea-Chuen Khor, Wieland Kiess, Marcus E Kleber, Wolfgang Koenig, Jaspal S Kooner, Antje Körner, Peter Kovacs, Aldi T Kraja, Alena Krajcoviechova, Holly Kramer, Bernhard K Krämer, Florian Kronenberg, Michiaki Kubo, Brigitte Kühnel, Mikko Kuokkanen, Johanna Kuusisto
发表日期
2019/6
期刊
Nature Genetics
卷号
51
期号
6
页码范围
957
出版商
Nature Publishing Group
简介
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through trans-ancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these, 147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and …
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M Wuttke, Y Li, M Li, KB Sieber, MF Feitosa, M Gorski… - Nature genetics, 2019