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The development of a city gradually fosters different functional regions, such as educational areas and business districts. In this paper, we propose a framework (titled DRoF) that Discovers Regions of different Functions in a city using both human mobility among regions and points of interests (POIs) located in a region. Specifically, we segment a city into disjointed regions according to major roads, such as highways and urban express ways. We infer the functions of each region using a topic-based inference model, which regards a region as a document, a function as a topic, categories of POIs (e.g., restaurants and shopping malls) as metadata (like authors, affiliations, and key words), and human mobility patterns (when people reach/leave a region and where people come from and leave for) as words. As a result, a region is represented by a distribution of functions, and a function is featured by a distribution of …