作者
Mei-Hsin Su, Ying-Hsiu Shih, Yen-Feng Lin, Pei-Chun Chen, Chia-Yen Chen, Po-Chang Hsiao, Yi-Jiun Pan, Yu-Li Liu, Shih-Jen Tsai, Po-Hsiu Kuo, Chi-Shin Wu, Yen-Tsung Huang, Shi-Heng Wang
发表日期
2022/5
期刊
Diabetologia
卷号
65
期号
5
页码范围
800-810
出版商
Springer Berlin Heidelberg
简介
Aims/hypothesis
Psychiatric disorders, such as schizophrenia (SCZ), major depressive disorder (MDD) and bipolar disorder (BPD), are highly comorbid with type 2 diabetes. However, the mechanisms underlying such comorbidity are understudied. This study explored the familial aggregation of common psychiatric disorders and type 2 diabetes by testing family history association, and investigated the shared genetic loading between them by testing the polygenic risk score (PRS) association.
Methods
A total of 105,184 participants were recruited from the Taiwan Biobank, and genome-wide genotyping data were available for 95,238 participants. The Psychiatric Genomics Consortium-derived PRS for SCZ, MDD and BPD was calculated. Logistic regression was used to estimate the OR with CIs between a family history of SCZ/MDD/BPD and a family history of type 2 diabetes, and between the PRS and the risk of type …
学术搜索中的文章
MH Su, YH Shih, YF Lin, PC Chen, CY Chen, PC Hsiao… - Diabetologia, 2022