作者
Yen-Feng Lin, Albert Vernon Smith, Thor Aspelund, Rebecca A Betensky, Jordan W Smoller, Vilmundur Gudnason, Lenore J Launer, Deborah Blacker
发表日期
2019/1/1
期刊
Alzheimer's & Dementia
卷号
15
期号
1
页码范围
65-75
出版商
No longer published by Elsevier
简介
Introduction
We sought to examine the genetic overlap between vascular pathologies and Alzheimer's disease (AD) dementia, and the potential mediating role of vascular pathologies between AD-related genetic variants and late-life cognition.
Methods
For 2907 stroke-free older individuals, we examined the association of polygenic risk scores for AD dementia (ADPRSs) with vascular pathologies and with cognition. Mediation analyses addressed whether association between ADPRSs and cognition was mediated by a vascular pathology.
Results
ADPRSs were associated with lobar cerebral microbleeds, white matter lesion load, and coronary artery calcification, mostly explained by single nucleotide polymorphisms in the 19q13 region. The effect of ADPRSs on cognition was partially but significantly mediated by cerebral microbleeds, white matter lesions, and coronary artery calcification.
Discussion
Our findings …
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