Background Lifestyle interventions produce short-term improvements in glycemia and
cardiovascular disease (CVD) risk factors in individuals with type 2 diabetes mellitus, but no …

OBJECTIVE—The effectiveness of intentional weight loss in reducing cardiovascular
disease (CVD) events in type 2 diabetes is unknown. This report describes 1-year changes …

Background Weight loss is recommended for overweight or obese patients with type 2
diabetes on the basis of short-term studies, but long-term effects on cardiovascular disease …

Background: The effect of multifaceted lifestyle interventions on clinically oriented outcomes
across a spectrum of metabolic risk factors and abnormal glucose is unclear. Purpose: To …

The increasing prevalence of type 2 diabetes throughout the world is now recognized as a
major health problem. A growing segment of the population has impaired glucose tolerance …

Given the array of adverse health consequences of obesity, including increased risk for type
2 diabetes mellitus (T2DM) and cardiovascular disease (CVD), the Look AHEAD trial (N …

OBJECTIVE Short-term weight loss improves cardiovascular disease (CVD) risk factors. We
sought to determine the longer-term effects of maintaining weight loss or, conversely …

Summary Background Findings from the Look AHEAD trial showed no significant reductions
in the primary outcome of cardiovascular disease incidence in adults with type 2 diabetes …

OBJECTIVE We reevaluated the Action for Health in Diabetes (Look AHEAD) intervention,
incorporating diabetes subgroups, to identify whether intensive lifestyle intervention (ILI) is …

Background Type 2 diabetes mellitus is increasingly common, primarily because of
increases in the prevalence of a sedentary lifestyle and obesity. Whether type 2 diabetes …