Virus-like particles: the future of microbial factories and cell-free systems as platforms for vaccine development

WA Rodríguez-Limas, K Sekar, KEJ Tyo - Current opinion in biotechnology, 2013 - Elsevier
Highlights▶ Microorganisms are inexpensive platforms to produce chimeric VLPs.▶
Bacteriophage-derived VLPs are excellent structures for drug delivery.▶ Microbial cell …

Synthetic biology for bioengineering virus‐like particle vaccines

HK Charlton Hume, J Vidigal… - Biotechnology and …, 2019 - Wiley Online Library
Vaccination is the most effective method of disease prevention and control. Many viruses
and bacteria that once caused catastrophic pandemics (eg, smallpox, poliomyelitis …

Development of virus‐like particles for diagnostic and prophylactic biomedical applications

B Schwarz, T Douglas - Wiley Interdisciplinary Reviews …, 2015 - Wiley Online Library
As ordered nanoscale architectures, viruses and virus‐like particles (VLP s) remain
unsurpassed by synthetic strategies to produce uniform and symmetric nanoparticles …

Virus-like particles: preparation, immunogenicity and their roles as nanovaccines and drug nanocarriers

S Nooraei, H Bahrulolum, ZS Hoseini… - Journal of …, 2021 - Springer
Virus-like particles (VLPs) are virus-derived structures made up of one or more different
molecules with the ability to self-assemble, mimicking the form and size of a virus particle but …

Applications of viral nanoparticles in medicine

I Yildiz, S Shukla, NF Steinmetz - Current opinion in biotechnology, 2011 - Elsevier
Several nanoparticle platforms are currently being developed for applications in medicine,
including both synthetic materials and naturally occurring bionanomaterials such as viral …

Virus-based nanocarriers for drug delivery

Y Ma, RJM Nolte, JJLM Cornelissen - Advanced drug delivery reviews, 2012 - Elsevier
New nanocarrier platforms based on natural biological building blocks offer great promises
in revolutionalizing medicine. The usage of specific protein cage structures: virus-like …

Production of virus-like particles for vaccines

J Fuenmayor, F Gòdia, L Cervera - New biotechnology, 2017 - Elsevier
Virus-like particles (VLPs) are nanostructures that resemble the structures of viruses. They
are composed of one or more structural proteins that can be arranged in several layers and …

Virus-like particles—universal molecular toolboxes

C Ludwig, R Wagner - Current opinion in biotechnology, 2007 - Elsevier
Virus-like particles (VLPs) are highly organised spheres that self-assemble from virus-
derived structural antigens. These stable and versatile subviral particles possess excellent …

Biomedical nanoparticle design: What we can learn from viruses

SM Figueroa, D Fleischmann, A Goepferich - Journal of Controlled Release, 2021 - Elsevier
Viruses are nanomaterials with a number of properties that surpass those of many synthetic
nanoparticles (NPs) for biomedical applications. They possess a rigorously ordered …

Production methods for viral particles

K Machida, H Imataka - Biotechnology letters, 2015 - Springer
Viral particles and virus-like particles (VLPs) or capsids are becoming important vehicles
and templates in bio-imaging, drug delivery and materials sciences. Viral particles are …