Insect cells as a production platform of complex virus-like particles

F Fernandes, AP Teixeira, N Carinhas… - Expert review of …, 2013 - Taylor & Francis
Virus-like particles (VLPs) are multiprotein structures that resemble the conformation of
native viruses but lack a viral genome, potentiating their application as safer and cheaper …

Plant viruses and bacteriophages for drug delivery in medicine and biotechnology

AE Czapar, NF Steinmetz - Current opinion in chemical biology, 2017 - Elsevier
Highlights•Plant viruses and bacteriophages can be regarded as natural nanoparticles.•Viral
nanoparticles are utilized in nanotechnology targeting diverse applications.•Viral capsids …

Bioengineering of virus-like particles as dynamic nanocarriers for in vivo delivery and targeting to solid tumours

IFBM Suffian, KT Al-Jamal - Advanced Drug Delivery Reviews, 2022 - Elsevier
Virus-like particles (VLPs) are known as self-assembled, non-replicative and non-infectious
protein particles, which imitate the formation and structure of original wild type viruses …

Structure-based design and experimental engineering of a plant virus nanoparticle for the presentation of immunogenic epitopes and as a drug carrier

C Arcangeli, P Circelli, M Donini… - Journal of …, 2014 - Taylor & Francis
Biomaterials research for the discovery of new generation nanoparticles is one of the most
active areas of nanotechnoloy. In the search of nature-made nanometer-sized objects, plant …

Virus-inspired nanosystems for drug delivery

Z Liao, L Tu, X Li, XJ Liang, S Huo - Nanoscale, 2021 - pubs.rsc.org
With over millions of years of evolution, viruses can infect cells efficiently by utilizing their
unique structures. Similarly, the drug delivery process is designed to imitate the viral …

High-throughput process development of an alternative platform for the production of virus-like particles in Escherichia coli

CL Effio, P Baumann, C Weigel, P Vormittag… - Journal of …, 2016 - Elsevier
The production of safe vaccines against untreatable or new diseases has pushed the
research in the field of virus-like particles (VLPs). Currently, a large number of commercial …

Current status and future challenges in transitioning to continuous bioprocessing of virus‐like particles

M Mittal, M Banerjee, LHL Lua… - Journal of Chemical …, 2022 - Wiley Online Library
Virus‐like particles (VLPs) are bioengineered protein complexes that can serve as
prophylactic vaccines due to favorable immunological characteristics like size, repetitive …

Quality assessment of virus-like particles at single particle level: a comparative study

I González-Domínguez, E Puente-Massaguer… - Viruses, 2020 - mdpi.com
Virus-like particles (VLPs) have emerged as a powerful scaffold for antigen presentation and
delivery strategies. Compared to single protein-based therapeutics, quality assessment …

Virus‐like particles as powerful vaccination strategy against human viruses

I Hadj Hassine, M Ben M'hadheb… - Reviews in Medical …, 2024 - Wiley Online Library
Nowadays, viruses are not only seen as causative agents of viral infectious diseases but
also as valuable research materials for various biomedical purposes, including recombinant …

Natural supramolecular building blocks: from virus coat proteins to viral nanoparticles

Z Liu, J Qiao, Z Niu, Q Wang - Chemical Society Reviews, 2012 - pubs.rsc.org
Viruses belong to a fascinating class of natural supramolecular structures, composed of
multiple copies of coat proteins (CPs) that assemble into different shapes with a variety of …