Plant-derived virus-like particles as vaccines

Q Chen, H Lai - Human vaccines & immunotherapeutics, 2013 - Taylor & Francis
Virus-like particles (VLPs) are self-assembled structures derived from viral antigens that
mimic the native architecture of viruses but lack the viral genome. VLPs have emerged as a …

Engineering tobacco mosaic virus and its virus‐like‐particles for synthesis of biotemplated nanomaterials

KZ Lee, V Basnayake Pussepitiyalage… - Biotechnology …, 2021 - Wiley Online Library
Biomolecules are increasingly attractive templates for the synthesis of functional
nanomaterials. Chief among them is the plant tobacco mosaic virus (TMV) due to its high …

Viral nanoparticles for drug delivery, imaging, immunotherapy, and theranostic applications

YH Chung, H Cai, NF Steinmetz - Advanced Drug Delivery Reviews, 2020 - Elsevier
Viral nanoparticles (VNPs) encompass a diverse array of naturally occurring nanomaterials
derived from plant viruses, bacteriophages, and mammalian viruses. The application and …

Physical, chemical, and synthetic virology: Reprogramming viruses as controllable nanodevices

MY Chen, SS Butler, W Chen… - Wiley Interdisciplinary …, 2019 - Wiley Online Library
The fields of physical, chemical, and synthetic virology work in partnership to reprogram
viruses as controllable nanodevices. Physical virology provides the fundamental biophysical …

Virus-like particles as a highly efficient vaccine platform: diversity of targets and production systems and advances in clinical development

N Kushnir, SJ Streatfield, V Yusibov - Vaccine, 2012 - Elsevier
Virus-like particles (VLPs) are a class of subunit vaccines that differentiate themselves from
soluble recombinant antigens by stronger protective immunogenicity associated with the …

Bio-mimic particles for the enhanced vaccinations: lessons learnt from the natural traits and pathogenic invasion

S Wu, Y Xia, Y Hu, G Ma - Advanced Drug Delivery Reviews, 2021 - Elsevier
In the combat against pathogens, the immune systems were evolved with the immune
recognitions against the various danger signals, which responded vigorously upon the …

Programmable polymorphism of a virus-like particle

AP Biela, A Naskalska, F Fatehi, R Twarock… - Communications …, 2022 - nature.com
Virus-like particles (VLPs) have significant potential as artificial vaccines and drug delivery
systems. The ability to control their size has wide ranging utility but achieving such …

Cargo retention inside P22 virus-like particles

K McCoy, E Selivanovitch, D Luque, B Lee… - …, 2018 - ACS Publications
Viral protein cages, with their regular and programmable architectures, are excellent
platforms for the development of functional nanomaterials. The ability to transform a virus …

Virus-like particles: flexible platforms for vaccine development

B Chackerian - Expert review of vaccines, 2007 - Taylor & Francis
Virus-like particles (VLPs) consist of viral structural proteins that, when overexpressed,
spontaneously self-assemble into particles that are antigenically indistinguishable from …

Virus like particle-based vaccines against emerging infectious disease viruses

J Liu, S Dai, M Wang, Z Hu, H Wang, F Deng - Virologica Sinica, 2016 - Springer
Emerging infectious diseases are major threats to human health. Most severe viral disease
outbreaks occur in developing regions where health conditions are poor. With increased …