Virus-like particles for drug delivery: a review of methods and applications

B Ikwuagwu, D Tullman-Ercek - Current Opinion in Biotechnology, 2022 - Elsevier
Highlights•Virus-like particles (VLPs) are versatile structuresfor drug-delivery applications.•
Mutations to VLP structural proteins can improve VLP drug delivery.•VLP–cargo loading …

Overcoming biological barriers by virus-like drug particles for drug delivery

YL Chen, CJ Bao, JL Duan, Y Xie, WL Lu - Advanced Drug Delivery …, 2023 - Elsevier
Virus-like particles (VLPs) have natural structural antigens similar to those found in viruses,
making them valuable in vaccine immunization. Furthermore, VLPs have demonstrated …

Virus-like particles as nanocarriers for intracellular delivery of biomolecules and compounds

J He, L Yu, X Lin, X Liu, Y Zhang, F Yang, W Deng - Viruses, 2022 - mdpi.com
Virus-like particles (VLPs) are nanostructures assemble from viral proteins. Besides widely
used for vaccine development, VLPs have also been explored as nanocarriers for cargo …

Engineering virus-like particles for antigen and drug delivery

BD Hill, A Zak, E Khera, F Wen - Current Protein and Peptide …, 2018 - ingentaconnect.com
Virus-like particles (VLPs) are nanoscale biological structures consisting of viral proteins
assembled in a morphology that mimic the native virion but do not contain the viral genetic …

Rational design of virus-like particles for nanomedicine

W Shan, C Wang, H Chen, L Ren - Accounts of Materials …, 2023 - ACS Publications
Conspectus With a plethora of advances in nanotechnology and biotechnology, the
development of natural particle-based drug delivery vectors is a rapidly emerging field; …

The role of virus-like particles in medical biotechnology

M Comas-Garcia, M Colunga-Saucedo… - Molecular …, 2020 - ACS Publications
Virus-like particles (VLPs) are protein-based, nanoscale, self-assembling, cage
architectures, which have relevant applications in biomedicine. They can be used for the …

Virus‐like particles: Next‐generation nanoparticles for targeted therapeutic delivery

MJ Rohovie, M Nagasawa… - … & translational medicine, 2017 - Wiley Online Library
Most drug therapies distribute the agents throughout the entire body, even though the drugs
are typically only needed at specific tissues. This often limits dosage and causes discomfort …

Virus-like particles: fundamentals and biomedical applications

JL Mejía-Méndez, R Vazquez-Duhalt… - International journal of …, 2022 - mdpi.com
Nanotechnology is a fast-evolving field focused on fabricating nanoscale objects for
industrial, cosmetic, and therapeutic applications. Virus-like particles (VLPs) are self …

Protein cargo encapsulation by virus‐like particles: Strategies and applications

D McNeale, N Dashti, LC Cheah… - Wiley Interdisciplinary …, 2023 - Wiley Online Library
Viruses and the recombinant protein cages assembled from their structural proteins, known
as virus‐like particles (VLPs), have gained wide interest as tools in biotechnology and …

Virus-like particle-based nanocarriers as an emerging platform for drug delivery

B Yuan, Y Liu, M Lv, Y Sui, S Hou, T Yang… - Journal of Drug …, 2023 - Taylor & Francis
New nanocarrier technologies are emerging, and they have great potential for improving
drug delivery, targeting efficiency and bioavailability. Virus-like particles (VLPs) are natural …