Bioengineering virus‐like particles as vaccines

LHL Lua, NK Connors, F Sainsbury… - Biotechnology and …, 2014 - Wiley Online Library
Virus‐like particle (VLP) technology seeks to harness the optimally tuned immunostimulatory
properties of natural viruses while omitting the infectious trait. VLPs that assemble from a …

Engineering virus-like particles for antigen and drug delivery

BD Hill, A Zak, E Khera, F Wen - Current Protein and Peptide …, 2018 - ingentaconnect.com
Virus-like particles (VLPs) are nanoscale biological structures consisting of viral proteins
assembled in a morphology that mimic the native virion but do not contain the viral genetic …

Synthetic biology for bioengineering virus‐like particle vaccines

HK Charlton Hume, J Vidigal… - Biotechnology and …, 2019 - Wiley Online Library
Vaccination is the most effective method of disease prevention and control. Many viruses
and bacteria that once caused catastrophic pandemics (eg, smallpox, poliomyelitis …

Virus-like particles: the future of microbial factories and cell-free systems as platforms for vaccine development

WA Rodríguez-Limas, K Sekar, KEJ Tyo - Current opinion in biotechnology, 2013 - Elsevier
Highlights▶ Microorganisms are inexpensive platforms to produce chimeric VLPs.▶
Bacteriophage-derived VLPs are excellent structures for drug delivery.▶ Microbial cell …

Towards the preparative and large-scale precision manufacture of virus-like particles

LK Pattenden, APJ Middelberg, M Niebert… - Trends in …, 2005 - cell.com
Virus-like particles (VLPs) are of interest in vaccination, gene therapy and drug delivery, but
their potential has yet to be fully realized. This is because existing laboratory processes …

Exploiting virus-like particles as innovative vaccines against emerging viral infections

H Jeong, BL Seong - Journal of Microbiology, 2017 - Springer
Emerging viruses pose a major threat to humans and livestock with global public health and
economic burdens. Vaccination remains an effective tool to reduce this threat, and yet, the …

Platforms, advances, and technical challenges in virus-like particles-based vaccines

R Gupta, K Arora, SS Roy, A Joseph… - Frontiers in …, 2023 - frontiersin.org
Viral infectious diseases threaten human health and global stability. Several vaccine
platforms, such as DNA, mRNA, recombinant viral vectors, and virus-like particle-based …

Production of virus-like particles for vaccines

J Fuenmayor, F Gòdia, L Cervera - New biotechnology, 2017 - Elsevier
Virus-like particles (VLPs) are nanostructures that resemble the structures of viruses. They
are composed of one or more structural proteins that can be arranged in several layers and …

Virus-like particles as a highly efficient vaccine platform: diversity of targets and production systems and advances in clinical development

N Kushnir, SJ Streatfield, V Yusibov - Vaccine, 2012 - Elsevier
Virus-like particles (VLPs) are a class of subunit vaccines that differentiate themselves from
soluble recombinant antigens by stronger protective immunogenicity associated with the …

[PDF][PDF] Advances and challenges in enveloped virus-like particle (VLP)-based vaccines

S Dai, H Wang, F Deng - Journal of …, 2018 - immunologyresearchjournal.com
Virus-like particles (VLPs) are highly organized particles that self-assemble from viral
structural proteins. Like parental viruses, VLPs can be either non-enveloped or enveloped …