Towards the preparative and large-scale precision manufacture of virus-like particles

LK Pattenden, APJ Middelberg, M Niebert… - Trends in …, 2005 - cell.com
Virus-like particles (VLPs) are of interest in vaccination, gene therapy and drug delivery, but
their potential has yet to be fully realized. This is because existing laboratory processes …

Bioengineering virus‐like particles as vaccines

LHL Lua, NK Connors, F Sainsbury… - Biotechnology and …, 2014 - Wiley Online Library
Virus‐like particle (VLP) technology seeks to harness the optimally tuned immunostimulatory
properties of natural viruses while omitting the infectious trait. VLPs that assemble from a …

Virus-like particles: the future of microbial factories and cell-free systems as platforms for vaccine development

WA Rodríguez-Limas, K Sekar, KEJ Tyo - Current opinion in biotechnology, 2013 - Elsevier
Highlights▶ Microorganisms are inexpensive platforms to produce chimeric VLPs.▶
Bacteriophage-derived VLPs are excellent structures for drug delivery.▶ Microbial cell …

[HTML][HTML] Construction and characterization of virus-like particles: a review

A Zeltins - Molecular biotechnology, 2013 - Springer
Over the last three decades, virus-like particles (VLPs) have evolved to become a widely
accepted technology, especially in the field of vaccinology. In fact, some VLP-based …

[HTML][HTML] In vitro assembly of virus-like particles and their applications

DT Le, KM Müller - Life, 2021 - mdpi.com
Virus-like particles (VLPs) are increasingly used for vaccine development and drug delivery.
Assembly of VLPs from purified monomers in a chemically defined reaction is advantageous …

Virus-like particles as vaccines and vessels for the delivery of small molecules

RL Garcea, L Gissmann - Current opinion in biotechnology, 2004 - Elsevier
Virus-like particles (VLPs) structurally mimic the viral capsid and have therefore been
extensively, and quite successfully, used as vaccine and viral serology reagents. The ability …

Engineering virus-like particles for antigen and drug delivery

BD Hill, A Zak, E Khera, F Wen - Current Protein and Peptide …, 2018 - ingentaconnect.com
Virus-like particles (VLPs) are nanoscale biological structures consisting of viral proteins
assembled in a morphology that mimic the native virion but do not contain the viral genetic …

Virus‐like particle engineering: from rational design to versatile applications

X Ding, D Liu, G Booth, W Gao, Y Lu - Biotechnology Journal, 2018 - Wiley Online Library
As mimicking natural virus structures, virus‐like particles (VLPs) have evolved to become a
widely accepted technology used for humans which are safe, highly efficacious, and …

Next generation vaccines and vectors: Designing downstream processes for recombinant protein‐based virus‐like particles

CL Effio, J Hubbuch - Biotechnology journal, 2015 - Wiley Online Library
In recent years, the development of novel recombinant virus‐like particles (VLPs) has been
generating new perspectives for the prevention of untreated and arising infectious diseases …

Escherichia coli‐based cell‐free synthesis of virus‐like particles

BC Bundy, MJ Franciszkowicz… - Biotechnology and …, 2008 - Wiley Online Library
Virus‐like particles (VLP) have received considerable attention for vaccine, drug delivery,
gene therapy and material science applications. Although the number of unique VLP and …