Ascertaining when and where genes are expressed is of crucial importance to
understanding or predicting the physiological role of genes and proteins and how they …

Background Mouse has served as an excellent model for studying human development and
diseases due to its similarity to human. Advances in transgenic and knockout studies in …

To provide a temporal framework for the genoarchitecture of brain development, we
generated in situ hybridization data for embryonic and postnatal mouse brain at seven …

Spatially resolved transcriptomic technologies are promising tools to study complex
biological processes such as mammalian embryogenesis. However, the imbalance between …

Advancing our understanding of embryonic development is heavily dependent on
identification of novel pathways or regulators. Although genome-wide techniques such as …

Spatial patterns of gene expression manifest at scales ranging from local (eg, cell-cell
interactions) to global (eg, body axis patterning). However, current spatial transcriptomics …

The early window of human embryogenesis is largely a black box for developmental
biologists. Here we probed the cellular diversity of 4–6 week human embryos when …

INTRODUCTION A reference atlas of human cell types is a major goal for the field. Here, we
set out to generate single-cell atlases of both gene expression (this study) and chromatin …

Molecular profiling of single cells has advanced our knowledge of the molecular basis of
development. However, current approaches mostly rely on dissociating cells from tissues …

During mammalian embryogenesis, differential gene expression gradually builds the identity
and complexity of each tissue and organ system. Here we systematically quantified mouse …