The translation of novel discoveries from basic research to clinical application is a long,
often inefficient, and thus costly process. Accordingly, the process of drug development …

Genetically modified animals are vital for gaining a proper understanding of disease
mechanisms. Mice have long been the mainstay of basic research into a wide variety of …

Genetically modified animal models are important for understanding the pathogenesis of
human disease and developing therapeutic strategies. Although genetically modified mice …

Progress in genetic engineering over the past few decades has made it possible to develop
methods that have led to the production of transgenic animals. The development of …

Since domestication, pigs have been used extensively in agriculture and kept as companion
animals. More recently they have been used in biomedical research, given they share many …

Animal models of human diseases play a critical role in medical research. Pigs are
anatomically and physiologically more like humans than are small rodents such as mice …

Genetically modified mice are powerful tools to investigate the molecular basis of many
human diseases. Mice are, however, of limited value for preclinical studies, because they …

The first transgenic pigs were generated for agricultural purposes about three decades ago.
Since then, the micromanipulation techniques of pig oocytes and embryos expanded from …

Although pigs are used widely as models of human disease, their utility as models has been
enhanced by genetic engineering. Initially, transgenes were added randomly to the genome …

Diabetes mellitus (DM) has emerged into a steadily increasing health problem and the
predicted future dimension of the global DM epidemic is alarming: an increase from currently …