In this study, we comprehensively charted the cellular landscape of colorectal cancer (CRC)
and well-matched liver metastatic CRC using single-cell and spatial transcriptome RNA …

Profiling heterologous cell types within tumors is essential to decipher tumor
microenvironment that shapes tumor progress and determines the outcome of therapeutic …

Colorectal cancer (CRC) is among the top 3 leading causes of cancer-related deaths, and
tumor malignant progression and metastases contribute to the high mortality of advanced …

Metastasized colorectal cancer (CRC) is associated with a poor prognosis and rapid
disease progression. Besides hepatic metastasis, peritoneal carcinomatosis is the major …

The tumor microenvironment is a complex ecosystem formed by distinct and interacting cell
populations, and its composition is related to cancer prognosis and response to clinical …

Liver metastasis, the leading cause of colorectal cancer mortality, exhibits a highly
heterogeneous and suppressive immune microenvironment. Here, we sequenced 97 …

Background Colorectal cancer (CRC) ranks as the second-leading cause of cancer-related
death worldwide with metastases being the main cause of cancer-related death. Here, we …

Background Distant metastasis accounts for 90% of deaths from colorectal cancer (CRC).
Genomic heterogeneity has been reported in various solid malignancies, but remains …

Here, we developed and comprehensively characterized a cellular model of colon cancer
progression consisting of four defined derivatives of a colon cancer cell line that resulted …

Colorectal cancer (CRC) is one of the most commonly diagnosed cancers in the world. A
genome-wide screening of transcriptome dysregulation between cancer and normal tissue …