Efficacy of the porcine species in biomedical research

K Gutierrez, N Dicks, WG Glanzner, LB Agellon… - Frontiers in …, 2015 - frontiersin.org
Since domestication, pigs have been used extensively in agriculture and kept as companion
animals. More recently they have been used in biomedical research, given they share many …

Unraveling the swine genome: implications for human health

LB Schook, TV Collares, KA Darfour-Oduro… - Annu. Rev. Anim …, 2015 - annualreviews.org
The pig was first used in biomedical research in ancient Greece and over the past few
decades has quickly grown into an important biomedical research tool. Pigs have genetic …

Advances in porcine genomics and proteomics—a toolbox for developing the pig as a model organism for molecular biomedical research

E Bendixen, M Danielsen, K Larsen… - Briefings in functional …, 2010 - academic.oup.com
Our current knowledge of human biology is often based on studying a wide range of animal
species. In particular, for understanding human diseases, the development of adequate …

Importance of the pig as a human biomedical model

JK Lunney, A Van Goor, KE Walker… - Science translational …, 2021 - science.org
Pigs have substantial potential as biomedical models for studying human developmental
processes, congenital diseases, and pathogen response mechanisms in addition to utility as …

Current progress of genetically engineered pig models for biomedical research

G Gün, WA Kues - Bioresearch open access, 2014 - liebertpub.com
The first transgenic pigs were generated for agricultural purposes about three decades ago.
Since then, the micromanipulation techniques of pig oocytes and embryos expanded from …

Genetically modified pigs for biomedical research

Y Luo, L Lin, L Bolund, TG Jensen… - Journal of inherited …, 2012 - Springer
During the last two decades, pigs have been used to develop some of the most important
large animal models for biomedical research. Advances in pig genome research, genetic …

Genetically engineered pigs as models for human disease

C Perleberg, A Kind… - Disease models & …, 2018 - journals.biologists.com
Genetically modified animals are vital for gaining a proper understanding of disease
mechanisms. Mice have long been the mainstay of basic research into a wide variety of …

Swine in biomedical research: creating the building blocks of animal models

L Schook, C Beattie, J Beever, S Donovan… - Animal …, 2005 - Taylor & Francis
The third conference focusing on Swine in Biomedical Research was held at the Fairmont
Hotel in Chicago from January 27 to 29, 2005, to identify areas of study or methodologies …

Transgenic pigs as models for translational biomedical research

B Aigner, S Renner, B Kessler, N Klymiuk… - Journal of molecular …, 2010 - Springer
The translation of novel discoveries from basic research to clinical application is a long,
often inefficient, and thus costly process. Accordingly, the process of drug development …

Application of genetically engineered pigs in biomedical research

M Hryhorowicz, D Lipiński, S Hryhorowicz… - Genes, 2020 - mdpi.com
Progress in genetic engineering over the past few decades has made it possible to develop
methods that have led to the production of transgenic animals. The development of …