Genetically modified animals are vital for gaining a proper understanding of disease
mechanisms. Mice have long been the mainstay of basic research into a wide variety of …

Genetically modified animal models are important for understanding the pathogenesis of
human disease and developing therapeutic strategies. Although genetically modified mice …

The translation of novel discoveries from basic research to clinical application is a long,
often inefficient, and thus costly process. Accordingly, the process of drug development …

Genetically modified mice are powerful tools to investigate the molecular basis of many
human diseases. Mice are, however, of limited value for preclinical studies, because they …

Animal models of human diseases play a critical role in medical research. Pigs are
anatomically and physiologically more like humans than are small rodents such as mice …

The genetics of the pig: Pigs as a model for biomedical sciences. Page 1 ©CAB International
2011. The Genetics of the Pig, 426 2nd Edn (eds MF Rothschild and A. Ruvinsky) Kristy N …

The first transgenic pigs were generated for agricultural purposes about three decades ago.
Since then, the micromanipulation techniques of pig oocytes and embryos expanded from …

Although pigs are used widely as models of human disease, their utility as models has been
enhanced by genetic engineering. Initially, transgenes were added randomly to the genome …

Swine models are relatively new kids on the block for modeling human health and diseases
when compared to rodents and dogs. Because of the similarity to humans in size …

Since domestication, pigs have been used extensively in agriculture and kept as companion
animals. More recently they have been used in biomedical research, given they share many …