Advances in pig models of human diseases

N Hou, X Du, S Wu - Animal Models and Experimental …, 2022 - Wiley Online Library
Animal models of human diseases play a critical role in medical research. Pigs are
anatomically and physiologically more like humans than are small rodents such as mice …

Genetically engineered pigs as models for human disease

C Perleberg, A Kind… - Disease models & …, 2018 - journals.biologists.com
Genetically modified animals are vital for gaining a proper understanding of disease
mechanisms. Mice have long been the mainstay of basic research into a wide variety of …

Genetically modified pig models for human diseases

N Fan, L Lai - Journal of genetics and genomics, 2013 - Elsevier
Genetically modified animal models are important for understanding the pathogenesis of
human disease and developing therapeutic strategies. Although genetically modified mice …

Current progress of genetically engineered pig models for biomedical research

G Gün, WA Kues - Bioresearch open access, 2014 - liebertpub.com
The first transgenic pigs were generated for agricultural purposes about three decades ago.
Since then, the micromanipulation techniques of pig oocytes and embryos expanded from …

Animal models got you puzzled?: think pig

EM Walters, Y Agca, V Ganjam… - Annals of the New York …, 2011 - Wiley Online Library
Swine are an excellent large animal model for human health and disease because their size
and physiology are similar to humans, in particular, with respect to the skin, heart …

Importance of the pig as a human biomedical model

JK Lunney, A Van Goor, KE Walker… - Science translational …, 2021 - science.org
Pigs have substantial potential as biomedical models for studying human developmental
processes, congenital diseases, and pathogen response mechanisms in addition to utility as …

[HTML][HTML] Advancing swine models for human health and diseases

EM Walters, RS Prather - Missouri medicine, 2013 - ncbi.nlm.nih.gov
Swine models are relatively new kids on the block for modeling human health and diseases
when compared to rodents and dogs. Because of the similarity to humans in size …

Transgenic pigs as models for translational biomedical research

B Aigner, S Renner, B Kessler, N Klymiuk… - Journal of molecular …, 2010 - Springer
The translation of novel discoveries from basic research to clinical application is a long,
often inefficient, and thus costly process. Accordingly, the process of drug development …

Genetically modified pigs to model human diseases

T Flisikowska, A Kind, A Schnieke - Journal of applied genetics, 2014 - Springer
Genetically modified mice are powerful tools to investigate the molecular basis of many
human diseases. Mice are, however, of limited value for preclinical studies, because they …

Swine in biomedical research: creating the building blocks of animal models

L Schook, C Beattie, J Beever, S Donovan… - Animal …, 2005 - Taylor & Francis
The third conference focusing on Swine in Biomedical Research was held at the Fairmont
Hotel in Chicago from January 27 to 29, 2005, to identify areas of study or methodologies …