Genetically modified mice are powerful tools to investigate the molecular basis of many
human diseases. Mice are, however, of limited value for preclinical studies, because they …

Genetically modified animals are vital for gaining a proper understanding of disease
mechanisms. Mice have long been the mainstay of basic research into a wide variety of …

Genetically modified animal models are important for understanding the pathogenesis of
human disease and developing therapeutic strategies. Although genetically modified mice …

The translation of novel discoveries from basic research to clinical application is a long,
often inefficient, and thus costly process. Accordingly, the process of drug development …

Animal models of human diseases play a critical role in medical research. Pigs are
anatomically and physiologically more like humans than are small rodents such as mice …

Although pigs are used widely as models of human disease, their utility as models has been
enhanced by genetic engineering. Initially, transgenes were added randomly to the genome …

Swine are increasingly studied as animal models of human disease. The anatomy, size,
longevity, physiology, immune system, and metabolism of swine are more like humans than …

The large animal model has gradually become an essential part of preclinical research
studies, relating to exploring the disease pathological mechanism, genic function, pharmacy …

Genetically modified swine hold great promise in the fields of agriculture and medicine.
Currently, these swine are being used to optimize production of quality meat, to improve our …

During the last two decades, pigs have been used to develop some of the most important
large animal models for biomedical research. Advances in pig genome research, genetic …