The first transgenic pigs were generated for agricultural purposes about three decades ago.
Since then, the micromanipulation techniques of pig oocytes and embryos expanded from …

The large animal model has gradually become an essential part of preclinical research
studies, relating to exploring the disease pathological mechanism, genic function, pharmacy …

Animal models of human diseases play a critical role in medical research. Pigs are
anatomically and physiologically more like humans than are small rodents such as mice …

Genetically modified animals are vital for gaining a proper understanding of disease
mechanisms. Mice have long been the mainstay of basic research into a wide variety of …

Progress in genetic engineering over the past few decades has made it possible to develop
methods that have led to the production of transgenic animals. The development of …

Pigs have substantial potential as biomedical models for studying human developmental
processes, congenital diseases, and pathogen response mechanisms in addition to utility as …

Swine are an excellent large animal model for human health and disease because their size
and physiology are similar to humans, in particular, with respect to the skin, heart …

Since domestication, pigs have been used extensively in agriculture and kept as companion
animals. More recently they have been used in biomedical research, given they share many …

This review is a short update on the diversity of swine biomedical models and the
importance of genomics in their continued development. The swine has been used as a …

Our current knowledge of human biology is often based on studying a wide range of animal
species. In particular, for understanding human diseases, the development of adequate …