Age is the main risk factor for the prevalent diseases of developed countries: cancer,
cardiovascular disease and neurodegeneration. The ageing process is deleterious for …

Aging is a universal biological process that increases the risk of multiple diseases including
cancer. Growing evidence shows that alterations in the genome and epigenome, driven by …

In this review we explore the importance of epigenetics as a contributing factor for aging
adult stem cells. We summarize the latest findings of epigenetic factors deregulated as adult …

Aging induces myriad cellular and, ultimately, physiological changes that cause a decline in
an organism's functional capabilities. Although the aging process and the pathways that …

The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

The role of epigenetics in the modulation of longevity has not been studied in humans. To
this aim,(1) we evaluated the DNA methylation from peripheral leukocytes of 21 female …

Senescence is the end point of a complex cellular response that proceeds through a set of
highly regulated steps. Initially, the permanent cell-cycle arrest that characterizes …

For several decades, understanding ageing and the processes that limit lifespan have
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …

Cancer and aging are accompanied by stereotyped changes to the epigenetic landscape,
including progressive loss of DNA methylation over gene-poor genomic regions (,). Global …

Research on longevity and healthy aging promises to increase our lifespan and decrease
the burden of degenerative diseases with important social and economic effects. Many …