The pathogenesis of sepsis involves complex interaction between the host and the infecting
microorganism. Bacterial recognition and signaling are essential functions of the cells of …

The outcome of sepsis and septic shock has not significantly improved in recent decades
despite the development of numerous drugs and supportive care therapies. To reduce …

Objectives: Up-and down-regulation of inflammatory response was described in blood cells
from septic patients, according to the stage of sepsis and the cells evaluated. This study …

Toll-like receptors (TLRs) are critical components of innate immunity. This study was
designed to evaluate differential expression of genes for TLR and associated signal …

Despite extensive research, bacterial sepsis and its associated systemic inflammation
remain a major cause of morbidity and mortality in the pediatric intensive care unit …

Despite a decrease in mortality over the last decade, sepsis remains the tenth leading
causes of death in western countries and one of the most common cause of death in …

The Toll-like receptors (TLRs) are a class of pattern recognition molecules with unique
functions in the innate and the acquired immune systems. The innate immune response has …

Sepsis remains a serious clinical problem because of high patient morbidity and mortality.
Despite significant advances in critical care, there is still no efficient causal therapy …

Septic shock is initiated by a systemic inflammatory response to microbial infection that
frequently leads to impaired perfusion and multiple organ failure. Because of its high risk of …

Toll-like receptors (TLRs) are recognition molecules that importantly contribute to the innate
immune response to bacterial and viral infections. Once TLRs sense the presence of …