Epigenetics of aging and aging-related disease

A Brunet, SL Berger - Journals of Gerontology Series A …, 2014 - academic.oup.com
Aging is associated with a wide range of human disorders, including cancer, diabetes,
cardiovascular, and neurodegenerative diseases. Long thought to be an inexorable road …

Epigenetic regulation of aging: implications for interventions of aging and diseases

K Wang, H Liu, Q Hu, L Wang, J Liu, Z Zheng… - Signal transduction and …, 2022 - nature.com
Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Epigenetic mechanisms of aging and aging-associated diseases

A la Torre, F Lo Vecchio, A Greco - Cells, 2023 - mdpi.com
Aging is an inevitable outcome of life, characterized by a progressive decline in tissue and
organ function. At a molecular level, it is marked by the gradual alterations of biomolecules …

The aging epigenome

LN Booth, A Brunet - Molecular cell, 2016 - cell.com
During aging, the mechanisms that normally maintain health and stress resistance strikingly
decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this …

Hot topics in epigenetic mechanisms of aging: 2011

M Berdasco, M Esteller - Aging cell, 2012 - Wiley Online Library
Aging is a complex process that results in compromised biological functions of the organism
and increased susceptibility to disease and death. Although the molecular basis of aging is …

Epigenetics of aging and aging-associated diseases

D Saul, RL Kosinsky - International journal of molecular sciences, 2021 - mdpi.com
Aging represents the multifactorial decline in physiological function of every living organism.
Over the past decades, several hallmarks of aging have been defined, including epigenetic …

The ageing epigenome and its rejuvenation

W Zhang, J Qu, GH Liu, JCI Belmonte - Nature reviews Molecular cell …, 2020 - nature.com
Ageing is characterized by the functional decline of tissues and organs and the increased
risk of ageing-associated disorders. Several 'rejuvenating'interventions have been proposed …

Epigenetic mechanisms of longevity and aging

P Sen, PP Shah, R Nativio, SL Berger - Cell, 2016 - cell.com
Aging is an inevitable outcome of life, characterized by progressive decline in tissue and
organ function and increased risk of mortality. Accumulating evidence links aging to genetic …

The role of epigenetics in aging and age-related diseases

V Calvanese, E Lara, A Kahn, MF Fraga - Ageing research reviews, 2009 - Elsevier
The role of epigenetics in aging and age-related diseases is a key issue in molecular
physiology and medicine because certain epigenetic factors are thought to mediate, at least …

Epigenetic control of aging

U Munoz-Najar, JM Sedivy - Antioxidants & redox signaling, 2011 - liebertpub.com
Organismal aging and longevity are influenced by many complex interacting factors.
Epigenetics has recently emerged as another possible determinant of aging. Here, we …