Psychosocial stress reversibly disrupts prefrontal processing and attentional control

C Liston, BS McEwen, BJ Casey - Proceedings of the …, 2009 - National Acad Sciences
Relatively little is known about the long-term neurobiological sequelae of chronic stress,
which predisposes susceptible patients to neuropsychiatric conditions affecting the …

Social defeat stress-specific increase in c-Fos expression in the extended amygdala in mice: Involvement of dopamine D1 receptor in the medial prefrontal cortex

C Numa, H Nagai, M Taniguchi, M Nagai… - Scientific reports, 2019 - nature.com
We recently reported that dopamine D1 receptor in the medial prefrontal cortex (mPFC) is
activated by subthreshold social defeat stress and suppresses the induction of depressive …

Social dominance modulates stress-induced neural activity in medial prefrontal cortex projections to the basolateral amygdala

BN Dulka, KS Bress, JA Grizzell, MA Cooper - Neuroscience, 2018 - Elsevier
Stress is a contributing factor in the etiology of several mood and anxiety disorders, and
social defeat models are used to investigate the biological basis of stress-related …

Social defeat stress causes selective attenuation of neuronal activity in the ventromedial prefrontal cortex

R Abe, S Okada, R Nakayama, Y Ikegaya, T Sasaki - Scientific Reports, 2019 - nature.com
The ventromedial prefrontal cortex (vmPFC) plays key roles in higher cognitive abilities,
including mental representations and the regulation of emotion. Previous studies have …

Chronic stress increases prefrontal inhibition: a mechanism for stress-induced prefrontal dysfunction

JM McKlveen, RL Morano, M Fitzgerald, S Zoubovsky… - Biological …, 2016 - Elsevier
Background Multiple neuropsychiatric disorders, eg, depression, are linked to imbalances in
excitatory and inhibitory neurotransmission and prefrontal cortical dysfunction, and are …

Sensitivity of the prefrontal GABAergic system to chronic stress in male and female mice: relevance for sex differences in stress-related disorders

R Shepard, CE Page, L Coutellier - Neuroscience, 2016 - Elsevier
Stress-induced modifications of the prefrontal cortex (PFC) are believed to contribute to the
onset of mood disorders, such as depression and anxiety, which are more prevalent in …

[HTML][HTML] Fluoxetine and environmental enrichment similarly reverse chronic social stress-related depression-and anxiety-like behavior, but have differential effects on …

ZA Cordner, I Marshall-Thomas, GJ Boersma… - Neurobiology of …, 2021 - Elsevier
The adverse effects of stress on brain and behavior have long been known and well-studied,
with abundant evidence linking stress to, among other things, mood and anxiety disorders …

Stress-induced alterations of mesocortical and mesolimbic dopaminergic pathways

F Quessy, T Bittar, LJ Blanchette, M Lévesque… - Scientific Reports, 2021 - nature.com
Our ability to develop the cognitive strategies required to deal with daily-life stress is
regulated by region-specific neuronal networks. Experimental evidence suggests that …

Stress-induced neuronal colony stimulating factor 1 provokes microglia-mediated neuronal remodeling and depressive-like behavior

ES Wohleb, R Terwilliger, CH Duman, RS Duman - Biological psychiatry, 2018 - Elsevier
Background Chronic stress exposure causes neuronal atrophy and synaptic deficits in the
medial prefrontal cortex (PFC), contributing to development of anxiety-and depressive-like …

Chronic stress causes projection-specific adaptation of amygdala neurons via small-conductance calcium-activated potassium channel downregulation

WH Zhang, WZ Liu, Y He, WJ You, JY Zhang, H Xu… - Biological …, 2019 - Elsevier
Background The role of the amygdala in mediating stress coping has been long
appreciated. However, basolateral amygdala (BLA) projection neurons (PNs) are organized …