C Numa, H Nagai, M Taniguchi, M Nagai… - Scientific reports, 2019 - nature.com
We recently reported that dopamine D1 receptor in the medial prefrontal cortex (mPFC) is activated by subthreshold social defeat stress and suppresses the induction of depressive …
Stress is a contributing factor in the etiology of several mood and anxiety disorders, and social defeat models are used to investigate the biological basis of stress-related …
The ventromedial prefrontal cortex (vmPFC) plays key roles in higher cognitive abilities, including mental representations and the regulation of emotion. Previous studies have …
JM McKlveen, RL Morano, M Fitzgerald, S Zoubovsky… - Biological …, 2016 - Elsevier
Background Multiple neuropsychiatric disorders, eg, depression, are linked to imbalances in excitatory and inhibitory neurotransmission and prefrontal cortical dysfunction, and are …
Stress-induced modifications of the prefrontal cortex (PFC) are believed to contribute to the onset of mood disorders, such as depression and anxiety, which are more prevalent in …
The adverse effects of stress on brain and behavior have long been known and well-studied, with abundant evidence linking stress to, among other things, mood and anxiety disorders …
F Quessy, T Bittar, LJ Blanchette, M Lévesque… - Scientific Reports, 2021 - nature.com
Our ability to develop the cognitive strategies required to deal with daily-life stress is regulated by region-specific neuronal networks. Experimental evidence suggests that …
ES Wohleb, R Terwilliger, CH Duman, RS Duman - Biological psychiatry, 2018 - Elsevier
Background Chronic stress exposure causes neuronal atrophy and synaptic deficits in the medial prefrontal cortex (PFC), contributing to development of anxiety-and depressive-like …
WH Zhang, WZ Liu, Y He, WJ You, JY Zhang, H Xu… - Biological …, 2019 - Elsevier
Background The role of the amygdala in mediating stress coping has been long appreciated. However, basolateral amygdala (BLA) projection neurons (PNs) are organized …