… Bipolar Disorder (BD) has been conceptualized as both a cyclic and a progressive disorder.
… deficiencies and telomere shortening) converge on a model of accelerated aging (AA). …

… of accelerated aging in BD. Results of this review strongly suggest BD as an accelerated aging
… Understanding the pathophysiology of aging in BD may ultimately lead to identification of …

… Bipolar disorder (BD) is associated with a reduced life expectancy compared to the general
… A model of accelerated aging has been proposed as a potential explanation to these …

… We hypothesized that, as seen in the periphery, an accelerated aging could also be
detected in the hippocampus of BD patients, as well as a cross-talk between all three biological …

… As BD has been associated with accelerated aging [21; 22], we hypothesized that GDF-15
is a potential biomarker of BD progression. Accordingly, the aims of this study were: i) to …

… BD may involve an accelerated epigenetic aging, which might … determine the accelerated
aging and its consequences in BD. … possible explanations for the accelerated aging seen in our …

… suggested the relevance of these epigenetic clocks to study accelerated aging in our sample.
This is consistent with previously reported epigenetic age estimations in individuals with …

Background: A mild pro-inflammatory status accompanies bipolar disorder (BD). Inflammation
can cause a shift in monoamine metabolism, thereby activating more cytotoxic pathways. …

… theory of bipolar disorder as an illness of accelerated aging: … Molecular correlates of aging
in mood disorders also include … stress in accelerated aging and major depressive disorder. …

… over the long-term course of illness in bipolar disorder. In a larger sample than the prior …
if older individuals with bipolar disorder were more likely to deviate from expected, age-based …