[HTML][HTML] Early detection of accelerated aging and cellular decline (AACD): A consensus statement

M Cesari, A Cherubini, JM Guralnik, A Beresniak… - Experimental …, 2021 - Elsevier
… The cellular hallmarks of accelerated aging and their clinical expression may be grouped …
terms ‘accelerated aging and cellular decline’ (AACD) and/or ‘age-associated cellular decline’. …

How cancer therapeutics cause accelerated aging: Insights from the hallmarks of aging

A Hill, J Sadda, MA LaBarge… - Journal of geriatric …, 2020 - geriatriconcology.net
… and are responsible for the aging phenotype with progressive functional decline [ … Cellular
senescence is a hallmark of aging that may be the result of many cancer therapeutics. Cellular

HIV-associated cellular senescence: a contributor to accelerated aging

J Cohen, C Torres - Ageing research reviews, 2017 - Elsevier
… (DLPC), a region of the brain associated with age-related decline. Thus, heroin appears
to be accelerating aging, and while markers of senescence were not explicitly examined in …

Reverse geroscience: how does exposure to early diseases accelerate the age‐related decline in health?

RA Kohanski, SG Deeks, C Gravekamp… - Annals of the New …, 2016 - Wiley Online Library
… to aging, has been less explored at the molecular/cellular level. Indeed, the role of childhood
or early adulthood exposure to chronic disease and/or treatment on accelerating aging

p63 deficiency activates a program of cellular senescence and leads to accelerated aging

WM Keyes, Y Wu, H Vogel, X Guo… - Genes & …, 2005 - genesdev.cshlp.org
… senescence caused by compromised p63 function might be an underlying cellular mechanism
for age-related decline at the organismal level. To investigate whether p63 deficiency …

Accelerated aging and aging process in the brain

NK Isaev, EE Genrikhs, MV Oborina… - Reviews in the …, 2018 - degruyter.com
… the problem of aging is the study of genetic pathologies leading to accelerated aging, such
as … It is possible that this decline in telomeric repair with aging has a functional significance to …

[HTML][HTML] A new role for oxidative stress in aging: the accelerated aging phenotype in Sod1−/− mice is correlated to increased cellular senescence

Y Zhang, A Unnikrishnan, SS Deepa, Y Liu, Y Li… - Redox biology, 2017 - Elsevier
… mice exhibited various accelerated aging phenotypes [eg, … accelerated aging. This then
raised the question of why we observed a significant decrease in lifespan and accelerated aging

The link between chronic stress and accelerated aging

YE Yegorov, AV Poznyak, NG Nikiforov, IA Sobenin… - Biomedicines, 2020 - mdpi.com
… Speaking of aging, it is worth mentioning the cellular aging and senescence. Although
the meaning of the term “cell senescence” seems obvious as it was first used to indicate the …

Psychological stress as a risk factor for accelerated cellular aging and cognitive decline: The involvement of microglia-neuron crosstalk

M Carrier, E Šimončičová, MK St-Pierre… - Frontiers in molecular …, 2021 - frontiersin.org
… MDD) and cognitive aging. Long-term psychological stress accelerates cellular aging and
predisposes to various diseases, including MDD, and cognitive decline. Among the underlying …

Dysregulated physiological stress systems and accelerated cellular aging

D Revesz, JE Verhoeven, Y Milaneschi… - … of aging, 2014 - Elsevier
… ANS factors form a cumulative impact on cellular aging. Although these results need further
… ) dysregulations actually lead to overall health decline, although 2 recent review papers …