Early-life stress and reproductive cost: A two-hit developmental model of accelerated aging?

I Shalev, J Belsky - Medical Hypotheses, 2016 - Elsevier
… Thereafter, we discuss the cost of reproduction and its effect on cellular aging in support of
reproduction that might link these two developmental frameworks to induce accelerate aging

LONG‐TERM COST OF REPRODUCTION WITH AND WITHOUT ACCELERATED SENESCENCE IN CALLOSOBRUCHUS MACULATUS: ANALYSIS OF AGE …

M Tatar, JR Carey, JW Vaupel - Evolution, 1993 - academic.oup.com
reproductive effort acceleratescost of' reproduction that are based on survivorship curves.
Such analyses are incomplete because the timing, duration, and magnitude of mortality costs

Phenotypes optimized for early‐life reproduction exhibit faster somatic deterioration with age, revealing a latent cost of high condition

MI Adler, M Telford… - Journal of Evolutionary …, 2016 - academic.oup.com
costs, if they preferentially invest resources into reproduction‐… accelerated somatic ageing
appears to be a cost of expressing a high‐condition phenotype optimized for reproduction

Reproduction predicts shorter telomeres and epigenetic age acceleration among young adult women

CP Ryan, MG Hayes, NR Lee, TW McDade… - Scientific reports, 2018 - nature.com
… effect of gravidity on cellular aging. Our findings provide evidence that reproduction in women
carries costs in the form of accelerated aging through two independent cellular pathways. …

Accelerated senescence as a cost of reproduction: Testing associations between oxidative stress and reproductive effort in rural and urban women

A Sancilio, G Jasienska, C Panter‐Brick… - American Journal of …, 2021 - Wiley Online Library
… the long-term costs of reproduction by examining associations between reproductive effort
and … the physiological mechanisms underlying the costs of reproduction during the lifetime of …

Costs of reproduction and ageing in the human female

G Jasienska - … Transactions of the Royal Society B, 2020 - royalsocietypublishing.org
costs of reproduction are related to lifespan [2]. In this review, I specifically ask whether
high reproductive … The first part of this article describes the costs of reproduction, including …

Contextual adversity, telomere erosion, pubertal development, and health: Two models of accelerated aging, or one?

J Belsky, I Shalev - Development and Psychopathology, 2016 - cambridge.org
… as well is that reproduction is energetically costly and can further accelerate aging via faster
… This observation has led the authors to propose a “two-hit” model of accelerated aging, one …

[HTML][HTML] Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives

MV Blagosklonny - Aging (Albany NY), 2010 - ncbi.nlm.nih.gov
aging. Mechanistically, hyper-activated mTOR (Target of Rapamycin) may render young males
robust at the cost of accelerated aging. … aging is not programmed, then reproductive aging

Horizons in the evolution of aging

T Flatt, L Partridge - BMC biology, 2018 - Springer
accelerate aging; conserved pathways control aging rate; senescence patterns are more
diverse than previously thought; aging … impact on survival and reproduction early as compared …

Reproductive senescence in a long-lived seabird: rates of decline in late-life performance are associated with varying costs of early reproduction

TE Reed, LEB Kruuk, S Wanless… - The American …, 2008 - journals.uchicago.edu
… This trade‐off between early‐ and late‐life reproduction was evident independent of the fact
… in reproductive performance are associated with varying costs of reproduction early in life. …