Role of SARS-CoV-2 spike-protein-induced activation of microglia and mast cells in the pathogenesis of neuro-COVID

TC Theoharides, D Kempuraj - Cells, 2023 - mdpi.com
… , microglia can change their numbers, morphological characteristics, molecular pattern, and
functions [132]. Activated microglia … released from activated microglia induce activation of …

Mitochondrial dynamics in SARS-COV2 spike protein treated human microglia: implications for neuro-COVID

E Clough, J Inigo, D Chandra, L Chaves… - Journal of Neuroimmune …, 2021 - Springer
… Cytokines activate microglia and astrocytes and activate microglia to secrete inflammatory
mediators, inducing altered neuroplasticity, and other neuropathologies resulting in neuro-…

Neuroinflammation and COVID-19

A Vanderheiden, RS Klein - Current opinion in neurobiology, 2022 - Elsevier
… mechanisms driving neurological disease in COVID-19 patients. … of mild COVID-19 found
that activated microglia persisted for … that microglia could be partly responsible for neurological

[HTML][HTML] Neuropathology of COVID-19 (neuro-COVID): clinicopathological update

JJ Lou, M Movassaghi, D Gordy, MG Olson… - Free …, 2021 - ncbi.nlm.nih.gov
… %) while severe neurologic disorders such as … COVID-19 patients. Common neuropathological
findings in the 184 patients reviewed include microglial activation (42.9%) with microglial

Microglia fighting for neurological and mental health: on the central nervous system frontline of COVID-19 pandemic

E Goncalves de Andrade, E Šimončičová… - … Cellular Neuroscience, 2021 - frontiersin.org
… the neurological abnormalities observed in COVID-19 patients could be related to the
neuroinflammation resulting from microglial responses to viral, hypoxic, and inflammatory insults. …

[HTML][HTML] The link between microglia and the severity of COVID‐19: The “two‐hit” hypothesis

J Bouayed, T Bohn - Journal of medical virology, 2021 - ncbi.nlm.nih.gov
… In this study, it was hypothesized that anosmia, a common neurological symptom in COVID‐19
… In summary, microglial hyper‐activation is associated with several diseases and serious …

Neurovascular injury with complement activation and inflammation in COVID-19

MH Lee, DP Perl, J Steiner, N Pasternack, W Li… - Brain, 2022 - academic.oup.com
… -COVID cases (mean ± SEM = 230.85 ± 30.57 versus 41.20 ± 9.35 cells/mm 2 , P < 0.0001).
Activated microglia … development of the neurological manifestations seen in acute COVID-19 …

Neuroinflammation and Its Impact on the Pathogenesis of COVID-19

MM Almutairi, F Sivandzade, TH Albekairi… - Frontiers in …, 2021 - frontiersin.org
COVID-19 and neuroinflammation-induced neurological alterations. Understanding the
signaling pathways activated within the CNS upon COVID-… Activated microglial cells induce the …

COVID‐19‐related neuropathology and microglial activation in elderly with and without dementia

TE Poloni, V Medici, M Moretti, SD Visonà… - Brain …, 2021 - Wiley Online Library
… ) appears to be a key factor in the pathogenesis of neurological damage, particularly in
the elderly or in patients with dementia. As recently pointed out, the exact mechanisms …

Neuropathobiology of COVID-19: the role for glia

ME Tremblay, C Madore, M Bordeleau… - … cellular neuroscience, 2020 - frontiersin.org
microglia, as well as of immune cells required for brain health, is considered critical in defining
the neurological damage and neurological outcome of COVID-… -activated microglial state, …