Association of adverse childhood experiences with accelerated epigenetic aging in midlife

K Kim, K Yaffe, DH Rehkopf, Y Zheng… - JAMA network …, 2023 - jamanetwork.com
… in epigenetic age comparing participants with 4 or more vs less than 4 adverse childhood
experiences. … Early adversities accelerate epigenetic aging into adulthood: a 10-year, within-…

[HTML][HTML] Accelerated epigenetic aging mediates link between adverse childhood experiences and depressive symptoms in older adults: Results from the Health and …

ET Klopack, EM Crimmins, SW Cole, TE Seeman… - SSM-population …, 2022 - Elsevier
… linked to accelerated biological aging. We hypothesize that accelerated epigenetic aging
may … This study examines 3 three second/third-generation epigenetic aging measures (viz., …

The association between adverse childhood experiences and epigenetic age acceleration in the Canadian longitudinal study on aging (CLSA)

D Joshi, A Gonzalez, D Lin, P Raina - Aging Cell, 2023 - Wiley Online Library
… with accelerated epigenetic aging, measured using the DNAm GrimAge but not DNAm
PhenoAge. When examining individual forms of adversity, childhood … GrimAge acceleration after …

[HTML][HTML] Maternal adverse childhood experiences before pregnancy are associated with epigenetic aging changes in their children

JC Nwanaji-Enwerem, L Van Der Laan, K Kogut… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
… We hypothesized that ACEs experienced by mothers during their own childhood would
accelerate epigenetic aging in their offspring, thus reflecting increased ACE-associated disease …

Early life adversity, pubertal timing, and epigenetic age acceleration in adulthood

EJ Hamlat, AA Prather, S Horvath… - Developmental …, 2021 - Wiley Online Library
epigenetic predictor of mortality risk. This study identifies a potential correlate or determinant
of accelerated epigenetic aging… age acceleration set in motion by childhood experiences. If …

Early life adversity and age acceleration at mid-life and older ages indexed using the next-generation GrimAge and Pace of Aging epigenetic clocks

C McCrory, G Fiorito, AM O'Halloran, S Polidoro… - …, 2022 - Elsevier
Childhood sexual abuse was the only ELA associated with EAA in this study, hastening the
pace of epigenetic aging … of 10 adverse childhood events measured prospectively between 0 …

[PDF][PDF] ADVERSE CHILDHOOD EXPERIENCES ASSOCIATED WITH EPIGENETIC AGE AND DEPRESSIVE SYMPTOMS IN OLDER ADULTS

E Klopack, J Carroll, E Crimmins, S Cole… - … in Aging, 2021 - pdfs.semanticscholar.org
… linked to accelerated biological aging. We hypothesized that accelerated epigenetic aging
may … This study examines secondgeneration epigenetic clocks (viz., GrimAge, PhenoAge, and …

Early adversities accelerate epigenetic aging into adulthood: a 10‐year, within‐subject analysis

WE Copeland, L Shanahan… - Journal of Child …, 2022 - Wiley Online Library
… Early adversities accelerate epigenetic aging long after they occur, in proportion to the total
number of such experiences, and in a manner consistent with a shared effect that crosses …

Adverse childhood experiences accelerate epigenetic aging, study finds

C Krewson - Contemporary OB/GYN, 2023 - search.proquest.com
… Multiple adverse outcomes have been … and accelerate the aging processes, and data have
indicated an association between ACEs and epigenetic pathways linked to biological aging.…

Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children

S Marini, KA Davis, TW Soare, Y Zhu… - …, 2020 - Elsevier
epigenetic age––known as “epigenetic clocks”––have been used to estimate accelerated
epigenetic aging… of adversity exposure on epigenetic age in children, none have investigated if …