[HTML][HTML] The human blood transcriptome in a large population cohort and its relation to aging and health

M Schmidt, L Hopp, A Arakelyan, H Kirsten… - Frontiers in big …, 2020 - frontiersin.org
… We characterized the human blood in terms of transcriptome types and functional gene
modules and their association with health-, lifestyle- and age-related phenotypes. It has impacts …

[HTML][HTML] Complex age-and cancer-related changes in human blood transcriptome—implications for pan-cancer diagnostics

F Qi, F Gao, Y Cai, X Han, Y Qi, J Ni, J Sun… - Frontiers in …, 2021 - frontiersin.org
… Finally, we show that age and presence of non-blood cancers change … We then
compared age-related transcriptome changes found in this study in blood with those found by …

Composition of the whole transcriptome in the human plasma: cellular source and modification by aging

T Nevalainen, A Autio, M Puhka, M Jylhä… - Experimental …, 2021 - Elsevier
… it to that of the peripheral blood mononuclear cell (PBMCs) of the … To assess aging-associated
changes in the plasma exRNA … processes as a result of aging. Additionally, plasma RNA …

[HTML][HTML] The transcriptional landscape of age in human peripheral blood

MJ Peters, R Joehanes, LC Pilling… - Nature …, 2015 - nature.com
… , cellular and tissue level 12 , a transcriptome analysis might lend greater insight than a …
chronological age. In contrast to the relatively invariable genome sequence, the transcriptome is …

[HTML][HTML] Aging whole blood transcriptome reveals candidate genes for SARS-CoV-2-related vascular and immune alterations

LG de Almeida Chuffa, PP Freire… - Journal of Molecular …, 2022 - Springer
… T cell exhaustion, we also mined the aging blood cell transcriptome for related markers [30]. …
varying with blood aging. Although CCL4L2 and DUSP4 genes increased over blood aging, …

[HTML][HTML] Transcriptomic profiles of aging in purified human immune cells

LM Reynolds, J Ding, JR Taylor, K Lohman, N Soranzo… - BMC genomics, 2015 - Springer
… of aging in humans. T cells and monocytes can be isolated from an easily accessible tissue
(blood), and both have known roles in the development of age… of the aging transcriptome, we …

Modeling the human aging transcriptome across tissues, health status, and sex

MN Shokhirev, AA Johnson - Aging cell, 2021 - Wiley Online Library
… A blood-specific aging model identified genes enriched for inflammatory response,
activation of the immune system, and negative regulation of cell death (Figure 5c). In the heart, …

[HTML][HTML] Transcriptomic landscape, gene signatures and regulatory profile of aging in the human brain

O González-Velasco, D Papy-García… - … et Biophysica Acta (BBA …, 2020 - Elsevier
human brain aging: focusing on sex differences in gene expression and splicing [11]; or
comparing the transcriptional landscape of brain tissue samples and blood … of transcriptome data …

[HTML][HTML] Deciphering dynamic changes of the aging transcriptome with COVID-19 progression and convalescence in the human blood

R Li, J Zou, D Pei, T Pan, B Yang, X Liu… - … and Targeted Therapy, 2023 - nature.com
… Thus, we hypothesized that aging-related cellular landscape … age-related genes in human
peripheral blood, we initially identified multiple gene clusters significantly correlated with age (…

[HTML][HTML] Transcriptome-wide assessment of human brain and lymphocyte senescence

MG Hong, AJ Myers, PKE Magnusson, JA Prince - PloS one, 2008 - journals.plos.org
… , on the effects of aging on gene expression at a transcriptome-level in the normal … The
second sample consisted of 1240 individuals ranging in age from 15-94 in which fresh blood