The complexity of Alzheimer's disease: an evolving puzzle

C Ferrari, S Sorbi - Physiological reviews, 2021 - journals.physiology.org
The history of Alzheimer’s disease (AD) started in 1907, but we needed to wait until the end
of the century to identify the components of pathological hallmarks and genetic subtypes and …

The puzzle of preserved cognition in the oldest old

O Bugiani - Neurological Sciences, 2020 - Springer
… To explain this, I suggest a parallel between brain ageing and Alzheimer’s disease (AD) …
more recently during the course of evolution. They deduced that neuronal vulnerability is related …

The puzzle of Alzheimer's disease (AD)

HD Lehmann - Medical hypotheses, 1992 - Elsevier
… In the evolutionary old part of the brain, the ratio of supplying cells per neuron may be lower
than in more recently evolved areas. With age, this ratio is lowered by naturally occurring …

[PDF][PDF] The paradox of research on dementia-Alzheimer's disease

ZS Khachaturian, AS Khachaturian - J Prev Alz Dis, 2016 - academia.edu
Presently research on dementia-Alzheimer’s disease is facing a crucial paradox. This enigma,
which marks a critical turning point in the history of the field, is the result of juxtaposing …

A turning point for Alzheimer's disease?

JC de la Torre - Biofactors, 2012 - Wiley Online Library
… in deciphering the puzzle of Alzheimer dementia was given by … subcellular level during
Alzheimer evolution makes single … of Alzheimer's Disease titled Basics of Alzheimer's Disease

[PDF][PDF] The evolution of preclinical Alzheimer's disease: implications for prevention trials

R Sperling, E Mormino, K Johnson - Neuron, 2014 - cell.com
… The challenge is that Ab is only one piece of the puzzle, and recent findings continue to support
the … Diagnosis-independent Alzheimer disease biomarker signature in cognitively normal …

[图书][B] How not to study a disease: the story of Alzheimer's

K Herrup - 2023 - books.google.com
… In the final chapters of the book, therefore, I offer a new vision of what Alzheimer's disease is
… to protect you from Alzheimer's disease. She rarely missed doing the crossword puzzle, she …

Scientific truth or false hope? Understanding Alzheimer's disease from an aging perspective

M Chen, JJ Maleski… - … of Alzheimer's Disease, 2011 - content.iospress.com
Alzheimer’s disease is misleading, since it defines senile dementia (SD), a long-known
incurable senile/geriatric condition, as a discrete/curable disease… An amazing conceptual puzzle

Perspectives on Alzheimer's disease: past, present and future

ZS Khachaturian - Alzheimer's Disease-Modernizing Concept …, 2012 - karger.com
… or academia simply cannot meet the needs of the rapidly-evolving scientific world. … , and
the field has attracted some of the best minds in the world to solve the puzzle of this brain …

[HTML][HTML] The maze of APP processing in Alzheimer's disease: where did we go wrong in reasoning?

M Chen - Frontiers in Cellular Neuroscience, 2015 - frontiersin.org
… with the progression of late-onset sporadic Alzheimer’s disease (sAD; also known as senile
dementia or … (This is the most bizarre puzzle in sAD that must be explained by any models). …