The role of the immune system in Alzheimer's disease

KM Wu, YR Zhang, YY Huang, Q Dong, L Tan… - Ageing research …, 2021 - Elsevier
… of immune cells in the AD trajectory and seek to demonstrate the crosstalk between the
immune cell … to the influences of gene susceptibility of immune cells for AD. We also consider …

Immune system response in Alzheimer's disease

PL McGeer, H Akiyama, S Itagaki… - Canadian Journal of …, 1989 - cambridge.org
… As immune cellular markers, antibodies were employed to the MHC group II glycoprotein
HLA-DR; to the common structural component of MHC class I glycoproteins, HLA-A,B,C; to the …

[HTML][HTML] The complexity of microglial interactions with innate and adaptive immune cells in Alzheimer's disease

SK Wyatt-Johnson, RR Brutkiewicz - Frontiers in aging neuroscience, 2020 - frontiersin.org
immune cells; however, there is a complexity of other immune cells present including … ,
neutrophils, and lymphocytic cells, such as natural killer (NK) cells, T cells, and B cells. In …

[HTML][HTML] Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer's disease

DA Dionisio-Santos, JA Olschowka… - Journal of …, 2019 - Springer
immune cells can aid in amyloid β clearance or modulate microglia responses, depending
on the cell type. As … and peripheral immune cells, which will be discussed later in this review. …

[HTML][HTML] Identification of immune cells and key genes associated with Alzheimer's disease

C Liu, X Zhang, H Chai, S Xu, Q Liu… - International Journal of …, 2022 - ncbi.nlm.nih.gov
… This study aimed to reveal 22 kinds of peripheral immune cell types and key … immune
cells are involved in the occurrence of AD. The molecular mechanisms between immune cells

[HTML][HTML] Innate immune cell death in neuroinflammation and Alzheimer's disease

Y Rajesh, TD Kanneganti - Cells, 2022 - mdpi.com
Cells of the innate immune system … immune cells can cause programmed cell death through
multiple pathways, including pyroptosis, apoptosis, necroptosis, and PANoptosis. The cell

[HTML][HTML] Single-cell RNA sequencing of peripheral blood reveals immune cell signatures in Alzheimer's disease

H Xu, J Jia - Frontiers in immunology, 2021 - frontiersin.org
… of peripheral immune cells in AD. This study aimed to explore the molecular basis of
peripheral immune cells and the features of adaptive immune repertoire at a single cell level. We …

[HTML][HTML] The roles of inflammation and immune mechanisms in Alzheimer's disease

LJ Van Eldik, MC Carrillo, PE Cole, D Feuerbach… - Alzheimer's & Dementia …, 2016 - Elsevier
… The Alzheimer's Association's Research roundtable met in April 2015 to explore the role of …
in the progression of Alzheimer's disease (AD). The ability of innate immune cells, particularly …

Alzheimer's disease variants with the genome-wide significance are significantly enriched in immune pathways and active in immune cells

Q Jiang, S Jin, Y Jiang, M Liao, R Feng, L Zhang… - Molecular …, 2017 - Springer
… + cells. In … immune system and active in immune cells. To a certain degree, the genetic
predisposition for development of AD is rooted in the immune system, rather than in neuronal cells

Targeting systemic innate immune cells as a therapeutic avenue for Alzheimer disease

V Pons, S Rivest - Pharmacological Reviews, 2022 - ASPET
… Antibody-based therapies allow to remove a great percentage of Aβ, suggesting that innate
immunity can play a great role in AD and a direct modulation of immune cells could lead to …