… locus and serum levels of IGF-1 in women (P = 0.005). In conclusion, the major locus determining
familial longevity up to high age … effects of the ApoE ε4 allele. No other major longevity …

… (age 11 to old age) cognitive change was 0.24 (±0.20), and the genetic correlation between
childhood and old age … may have a role in cognitive change between childhood and old age. …

… , with a higher concentration for the DD genotype, it is unrelated to blood pressure and
hypertension in adult populations13•26• However, such a correlation may arise at a very old age, …

… We replicated and confirmed APOE as the major genetic determinant of survival into old
age… Of these, two haplotypes including the APOE locus and four redundant haplotypes from a …

… age dependent association reported by other groups, and our results, is that the APOE locus
… “All controls were selected according to our age-selection criterion of being older than two …

… % of deaths) in old age. Our results emphasize that variation at the APOE locus has a higher
… the risk of cardiovascular disease in old age [Eichner et al., 1993; Wilson et al., 1994, 1996]. …

… We investigated to what extent apoE plasma levels are … influencing apoE levels is to
be found at the APOE locus or … Adult apoE levels increase significantly with older age (b1¼0.…

… 4,139 individuals that reached ages achieved by less than 1% … the role of the APOE alleles
in survival to extreme old age. … locus with a negative effect on longevity, in addition to APOE ε …

… Genome-wide association study identifies a single major locus contributing to survival into
old age; the APOE locus revisited. Aging Cell 2011;10:686–698. Crossref, Medline, Google …

… the Ely cohort into those cases aged 84 or less and those aged older than 84 years. The …
Resolution of the roles of different apoE and possibly different apoCI alleles will be critical …