Neurological complications associated with the blood-brain barrier damage induced by the inflammatory response during SARS-CoV-2 infection

I Alquisiras-Burgos, I Peralta-Arrieta… - Molecular …, 2021 - Springer
… and brain damage. Then, we analyzed and described the possible mechanisms causative
of brain injury after SARS-CoV-2 infection. We proposed that potential routes of SARS-CoV-2 …

Interactions of SARS-CoV-2 with the bloodbrain barrier

MA Erickson, EM Rhea, RC Knopp… - International Journal of …, 2021 - mdpi.com
brain and blood compartments. In this review, we discuss mechanisms by which SARS-CoV-…
-2 entry and infection, which could contribute to neuronal and endothelial damage and loss. …

Neuropathophysiology of coronavirus disease 2019: neuroinflammation and blood brain barrier disruption are critical pathophysiological processes that contribute to …

MO Welcome, NE Mastorakis - Inflammopharmacology, 2021 - Springer
… of SARS-CoV-2 induced cerebral damageSARS-CoV-2 induced cerebral damage. Potential
molecular targets and emerging therapeutics for SARS-CoV-2 induced neurologic damage

[HTML][HTML] Blood-brain barrier damage is pivotal for SARS-CoV-2 infection to the central nervous system

J Rodríguez-Morales… - Experimental …, 2022 - ncbi.nlm.nih.gov
… structural damage to the BBB elicits the SARS-CoV-2 infection to the CNS. Herein, we present
the case reports of two patients with a brain … a possible BBB damage which highlights the …

SARS-CoV-2 crosses the bloodbrain barrier accompanied with basement membrane disruption without tight junctions alteration

L Zhang, L Zhou, L Bao, J Liu, H Zhu, Q Lv… - Signal transduction and …, 2021 - nature.com
… of SARS-CoV-2 spike protein (SARS-CoV-2-S) in the brains of … the co-localization of
SARS-CoV-2-S with blood vessels in the … a clue that SARS-CoV-2 infection could damage BBB via …

SARS-CoV-2 poorly replicates in cells of the human blood-brain barrier without associated deleterious effects

O Constant, J Barthelemy, K Bollore, E Tuaillon… - Frontiers in …, 2021 - frontiersin.org
… We observed low replication of SARS-CoV-2 that was accompanied by very moderate …
of brain access following SARS-CoV-2 infection does not seem to be directed by brain

SARS-COV2 alters blood brain barrier integrity contributing to neuro-inflammation

JL Reynolds, SD Mahajan - Journal of Neuroimmune Pharmacology, 2021 - Springer
… , that SARS-COV-2 associated endothelial cell dysfunction preludes the neuropathology
associated with SARS-COV-… or therapies that prevent BBB damage may be effective in treating …

[PDF][PDF] The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2

S Krasemann, U Haferkamp, S Pfefferle, MS Woo… - Stem cell reports, 2022 - cell.com
… in their paracellular tightness, we found SARS-CoV-2 in the … transport of virus across the
blood-brain barrier (BBB) in vitro. … the respiratory system, damage and dysfunction have also …

Role of aging in BloodBrain Barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19

D Adesse, L Gladulich, L Alvarez-Rosa… - … and Barriers of the CNS, 2022 - Springer
… the impact of SARS-CoV-2 on the NVU, the expression profile of SARS-CoV-2 receptors in
the … can also enter the fourth ventricle directly through a damaged blood–CSF barrier. Indeed, …

Bloodbrain barrier injury and neuroinflammation induced by SARS-CoV-2 in a lung–brain microphysiological system

P Wang, L Jin, M Zhang, Y Wu, Z Duan, Y Guo… - Nature Biomedical …, 2023 - nature.com
… alveolus and bloodbrain barrier (BBB) tissue chips that recapitulates neuropathogenesis
associated with infection by SARS-CoV-2. Direct exposure of the BBB chip to SARS-CoV-2 …